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Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam

Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA an...

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Autores principales: Duong-Quy, Sy, Hua-Huy, Thong, Tran-Mai-Thi, Huyen-Tran, Le-Dong, Nhat-Nam, Craig, Timothy J., Dinh-Xuan, Anh-Tuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737467/
https://www.ncbi.nlm.nih.gov/pubmed/26881073
http://dx.doi.org/10.1155/2016/3050918
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author Duong-Quy, Sy
Hua-Huy, Thong
Tran-Mai-Thi, Huyen-Tran
Le-Dong, Nhat-Nam
Craig, Timothy J.
Dinh-Xuan, Anh-Tuan
author_facet Duong-Quy, Sy
Hua-Huy, Thong
Tran-Mai-Thi, Huyen-Tran
Le-Dong, Nhat-Nam
Craig, Timothy J.
Dinh-Xuan, Anh-Tuan
author_sort Duong-Quy, Sy
collection PubMed
description Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics. Methods. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG). Results. According to the result of PSG, 82 persons were divided into two groups: control subjects (n = 30; 54 ± 14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n = 52; 53 ± 12 years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3 ± 1.9 ppb) was significantly higher than pre-PSG CANO (4.0 ± 1.7 ppb; P < 0.001). Significant correlations have been found between CANO and AHI (P < 0.001) and between CANO and nadir SpO(2) (P < 0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%. Conclusion. Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms.
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spelling pubmed-47374672016-02-15 Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam Duong-Quy, Sy Hua-Huy, Thong Tran-Mai-Thi, Huyen-Tran Le-Dong, Nhat-Nam Craig, Timothy J. Dinh-Xuan, Anh-Tuan Pulm Med Research Article Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics. Methods. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG). Results. According to the result of PSG, 82 persons were divided into two groups: control subjects (n = 30; 54 ± 14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n = 52; 53 ± 12 years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3 ± 1.9 ppb) was significantly higher than pre-PSG CANO (4.0 ± 1.7 ppb; P < 0.001). Significant correlations have been found between CANO and AHI (P < 0.001) and between CANO and nadir SpO(2) (P < 0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%. Conclusion. Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms. Hindawi Publishing Corporation 2016 2016-01-13 /pmc/articles/PMC4737467/ /pubmed/26881073 http://dx.doi.org/10.1155/2016/3050918 Text en Copyright © 2016 Sy Duong-Quy et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Duong-Quy, Sy
Hua-Huy, Thong
Tran-Mai-Thi, Huyen-Tran
Le-Dong, Nhat-Nam
Craig, Timothy J.
Dinh-Xuan, Anh-Tuan
Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
title Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
title_full Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
title_fullStr Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
title_full_unstemmed Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
title_short Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
title_sort study of exhaled nitric oxide in subjects with suspected obstructive sleep apnea: a pilot study in vietnam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737467/
https://www.ncbi.nlm.nih.gov/pubmed/26881073
http://dx.doi.org/10.1155/2016/3050918
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