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Phospholipid Scramblases
The distribution of phospholipid types between the two leaflets of a membrane bilayer is a controlled feature of membrane structure. One of the two membrane catalytic activities governing this distribution randomizes the composition of the two leaflets—the phospholipid scramblases. Two proteins (Xkr...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Libertas Academica
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737519/ https://www.ncbi.nlm.nih.gov/pubmed/26843813 http://dx.doi.org/10.4137/LPI.S31785 |
| Sumario: | The distribution of phospholipid types between the two leaflets of a membrane bilayer is a controlled feature of membrane structure. One of the two membrane catalytic activities governing this distribution randomizes the composition of the two leaflets—the phospholipid scramblases. Two proteins (Xkr8 and TMEM16F) required for the activation of these activities have been identified. One of these proteins (TMEM16F) is quite clearly a scramblase itself and provides insight into the mechanism by which transbilayer phospholipid movement is facilitated. |
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