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Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep

Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within...

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Autores principales: Mitra, Anish, Snyder, Abraham Z, Tagliazucchi, Enzo, Laufs, Helmut, Raichle, Marcus E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737658/
https://www.ncbi.nlm.nih.gov/pubmed/26551562
http://dx.doi.org/10.7554/eLife.10781
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author Mitra, Anish
Snyder, Abraham Z
Tagliazucchi, Enzo
Laufs, Helmut
Raichle, Marcus E
author_facet Mitra, Anish
Snyder, Abraham Z
Tagliazucchi, Enzo
Laufs, Helmut
Raichle, Marcus E
author_sort Mitra, Anish
collection PubMed
description Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. Broadly, ordered propagation is preserved within traditionally defined RSNs but lost between RSNs. Additionally, propagation between cerebral cortex and subcortical structures reverses directions, and intra-cortical propagation becomes reorganized, especially in visual and sensorimotor cortices. These findings show that propagated rs-fMRI activity informs theoretical accounts of the neural functions of sleep. DOI: http://dx.doi.org/10.7554/eLife.10781.001
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spelling pubmed-47376582016-02-04 Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep Mitra, Anish Snyder, Abraham Z Tagliazucchi, Enzo Laufs, Helmut Raichle, Marcus E eLife Human Biology and Medicine Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. Broadly, ordered propagation is preserved within traditionally defined RSNs but lost between RSNs. Additionally, propagation between cerebral cortex and subcortical structures reverses directions, and intra-cortical propagation becomes reorganized, especially in visual and sensorimotor cortices. These findings show that propagated rs-fMRI activity informs theoretical accounts of the neural functions of sleep. DOI: http://dx.doi.org/10.7554/eLife.10781.001 eLife Sciences Publications, Ltd 2015-11-09 /pmc/articles/PMC4737658/ /pubmed/26551562 http://dx.doi.org/10.7554/eLife.10781 Text en © 2015, Mitra et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Human Biology and Medicine
Mitra, Anish
Snyder, Abraham Z
Tagliazucchi, Enzo
Laufs, Helmut
Raichle, Marcus E
Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
title Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
title_full Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
title_fullStr Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
title_full_unstemmed Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
title_short Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
title_sort propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737658/
https://www.ncbi.nlm.nih.gov/pubmed/26551562
http://dx.doi.org/10.7554/eLife.10781
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