“DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint

The breast cancer associated gene 1 (BRCA1) contains 3 domains: an N-terminal RING domain with ubiquitin E3 ligase activity, C-terminal BRCT protein interaction domain and a central region. RING and BRCT domains are well characterized, yet the function of the central region remains unclear. In this...

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Detalles Bibliográficos
Autores principales: Masuda, Takaaki, Xu, Xiaoling, Dimitriadis, Emilios K., Lahusen, Tyler, Deng, Chu-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737671/
https://www.ncbi.nlm.nih.gov/pubmed/26884712
http://dx.doi.org/10.7150/ijbs.14242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737671/
https://www.ncbi.nlm.nih.gov/pubmed/26884712
http://dx.doi.org/10.7150/ijbs.14242

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