Cargando…

“DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint

The breast cancer associated gene 1 (BRCA1) contains 3 domains: an N-terminal RING domain with ubiquitin E3 ligase activity, C-terminal BRCT protein interaction domain and a central region. RING and BRCT domains are well characterized, yet the function of the central region remains unclear. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Masuda, Takaaki, Xu, Xiaoling, Dimitriadis, Emilios K., Lahusen, Tyler, Deng, Chu-Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737671/ https://www.ncbi.nlm.nih.gov/pubmed/26884712 http://dx.doi.org/10.7150/ijbs.14242

Ejemplares similares

SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
por: Wang, Rui-Hong, et al.
Publicado: (2014)

Protein Stability and Functional Characterization of Intra-Melanosomal Domain of Human Recombinant Tyrosinase-Related Protein 1
por: Dolinska, Monika B., et al.
Publicado: (2020)

Replication fork integrity and intra-S phase checkpoint suppress gene amplification
por: Kondratova, Anna, et al.
Publicado: (2015)

BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
por: Chen, Qiang, et al.
Publicado: (2020)

BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis
por: Chen, Qiang, et al.
Publicado: (2020)

Loss of CCDC6 Affects Cell Cycle through Impaired Intra-S-Phase Checkpoint Control
por: Thanasopoulou, Angeliki, et al.
Publicado: (2012)

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
por: Deng, Chu-Xia
Publicado: (2006)

On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway
por: Ciardo, Diletta, et al.
Publicado: (2019)

Chromatin De-Compaction By The Nucleosomal Binding Protein HMGN5 Impairs Nuclear Sturdiness
por: Furusawa, Takashi, et al.
Publicado: (2015)

Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors
por: Zhou, Zhijun, et al.
Publicado: (2021)

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners
por: Melters, Daniël P., et al.
Publicado: (2019)

SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability
por: Giráldez, Servando, et al.
Publicado: (2014)

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response
por: Simhadri, Srilatha, et al.
Publicado: (2018)

In vitro phosphorylation of BRCA2 by the checkpoint kinase CHEK2
por: Kim, S, et al.
Publicado: (2008)

The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
por: Bui, Minh, et al.
Publicado: (2013)

Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy
por: Rakshit, Tatini, et al.
Publicado: (2020)

The Intra-S Checkpoint Responses to DNA Damage
por: Iyer, Divya Ramalingam, et al.
Publicado: (2017)

Safety and durability of AGT103-T autologous T cell therapy for HIV infection in a Phase 1 trial
por: Muvarak, Nidal, et al.
Publicado: (2022)

BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding
por: Burke, Leslie J., et al.
Publicado: (2018)

Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress
por: Westhorpe, Rose, et al.
Publicado: (2020)

Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors
por: Choi, Eun Kyung, et al.
Publicado: (2018)

Organization of membrane motor in outer hair cells: an atomic force microscopic study
por: Sinha, Ghanshyam P., et al.
Publicado: (2009)

Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells
por: Vazquez-Ortiz, Guelaguetza, et al.
Publicado: (2014)

Use of REBOA to stabilize in-hospital iatrogenic intra-abdominal hemorrhage
por: Goodenough, Christopher J, et al.
Publicado: (2018)

Intergenic Regions of Saccharomycotina Yeasts are Enriched in Potential to Encode Transmembrane Domains
por: Tassios, Emilios, et al.
Publicado: (2023)

A New Noncoding RNA Arranges Bacterial Chromosome Organization
por: Qian, Zhong, et al.
Publicado: (2015)

Multitumor Case Series of Germline BRCA1, BRCA2 and CHEK2-Mutated Patients Responding Favorably on Immune Checkpoint Inhibitors
por: Kinget, Lisa, et al.
Publicado: (2021)

Temporal separation of replication and recombination requires the intra-S checkpoint
por: Meister, Peter, et al.
Publicado: (2005)

The role of Rak in the regulation of stability and function of BRCA1
por: Kim, Jung-Lye, et al.
Publicado: (2015)

Sulfated endospermic nanocellulose crystals prevent the transmission of SARS-CoV-2 and HIV-1
por: Barriga, Enrique Javier Carvajal, et al.
Publicado: (2022)

Sulfated endospermic nanocellulose crystals prevent the transmission of SARS-CoV-2 and HIV-1
por: Carvajal-Barriga, Enrique Javier, et al.
Publicado: (2023)

Killing the umpire: cooperative defects in mitotic checkpoint and BRCA2 genes on the road to transformation
por: McKeon, Frank
Publicado: (1999)

A PP1-binding motif present in BRCA1 plays a role in its DNA repair function
por: Yu, Young-Mi, et al.
Publicado: (2008)

NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models
por: Liou, Mei-Ling, et al.
Publicado: (2022)

Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions
por: Michelena, Jone, et al.
Publicado: (2019)

Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer
por: Lee, Chee Khoon, et al.
Publicado: (2019)

The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair
por: Chen, Bert Yu-Hung, et al.
Publicado: (2014)

Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells
por: Chaudhuri, Arnab Ray, et al.
Publicado: (2016)

A BRCA2 germline mutation and high expression of immune checkpoints in a TNBC patient
por: Han, Yuyi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2bmaf4qm4j3u8fb1uir45tcic8