Cargando…

Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been defined as a unique subgroup in the new classification of myeloid neoplasm, and the AML patients with mutated NPM1 frequently present extramedullary infiltration, but how NPM1 mutants regulate this process remains elusive. In th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xian, Jingrong, Shao, Huiyuan, Chen, Xianchun, Zhang, Shuaishuai, Quan, Jing, Zou, Qin, Jin, Hongjun, Zhang, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737672/ https://www.ncbi.nlm.nih.gov/pubmed/26884713 http://dx.doi.org/10.7150/ijbs.13382

Ejemplares similares

Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression
por: Zhang, Shuaishuai, et al.
Publicado: (2016)

The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b
por: Zou, Qin, et al.
Publicado: (2016)

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway
por: Gillies, Taryn E, et al.
Publicado: (2020)

Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia
por: Tan, Shi, et al.
Publicado: (2011)

Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway
por: Li, Min, et al.
Publicado: (2023)

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
por: Vassiliou, George S., et al.
Publicado: (2011)

Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development
por: Barbieri, Elisa, et al.
Publicado: (2016)

Yunnanterpene G, a spiro-triterpene from the roots of Cimicifuga foetida, downregulates the expression of CD147 and MMPs in PMA differentiated THP-1 cells
por: Lu, Ni-Hong, et al.
Publicado: (2018)

NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells
por: Zou, Qin, et al.
Publicado: (2017)

Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer
por: Lee, Jennifer J., et al.
Publicado: (2021)

Quantitative Detection of Circulating Nucleophosmin Mutations DNA in the Plasma of Patients with Acute Myeloid Leukemia
por: Quan, Jing, et al.
Publicado: (2015)

NUCLEOPHOSMIN MUTATION IS DOUBLE TROUBLE
por: Robinson, Richard
Publicado: (2008)

Nucleophosmin in Its Interaction with Ligands
por: Cela, Ilaria, et al.
Publicado: (2020)

Metastasis-associated gene MAPK15 promotes the migration and invasion of osteosarcoma cells via the c-Jun/MMPs pathway
por: Su, Zexin, et al.
Publicado: (2020)

Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells
por: Liu, Yan, et al.
Publicado: (2012)

TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells
por: Gomes, Luciana R, et al.
Publicado: (2012)

Matrix Metalloproteinases (MMPs) and Inhibitors of MMPs in the Avian Reproductive System: An Overview
por: Hrabia, Anna
Publicado: (2021)

Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway
por: Makdissy, Nehman, et al.
Publicado: (2015)

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression
por: Cheng, Hsin-Lin, et al.
Publicado: (2016)

Whitmania Pigra Whitman Extracts Inhibit Lipopolysaccharide Induced Rat Vascular Smooth Muscle Cells Migration and their Adhesion Ability to THP-1 and RAW 264.7 Cells
por: Li, Shuaishuai, et al.
Publicado: (2017)

MMPs rearrange DNA
por: LeBrasseur, Nicole
Publicado: (2005)

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
por: Merchant, Mark, et al.
Publicado: (2017)

RAS Dimers: The Novice Couple at the RAS-ERK Pathway Ball
por: Herrero, Ana, et al.
Publicado: (2021)

Prevalence and patterns of mutations in RAS/RAF/MEK/ERK/MAPK signaling pathway in colorectal cancer in North Africa
por: Jafari, Meryem, et al.
Publicado: (2022)

Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer
por: Rubio, Karla, et al.
Publicado: (2023)

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
por: Bonetti, Paola, et al.
Publicado: (2008)

MAPK-ERK Pathway
por: Park, Jong-In
Publicado: (2023)

Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity
por: Zheng, Pei, et al.
Publicado: (2017)

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
por: Merchant, Mark, et al.
Publicado: (2018)

VEGF promotes migration and invasion by regulating EMT and MMPs in nasopharyngeal carcinoma
por: Chen, Li, et al.
Publicado: (2020)

Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma
por: LIU, MEI, et al.
Publicado: (2015)

RAS MAPK inhibitors deregulation in leukemia
por: Pasmant, Eric, et al.
Publicado: (2015)

TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
por: Campbell, Paul M, et al.
Publicado: (2010)

Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells
por: Zhou, Yuan, et al.
Publicado: (2015)

Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer
por: Fernández Montes, A., et al.
Publicado: (2022)

ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer
por: Roseweir, Antonia K., et al.
Publicado: (2018)

Molecules that target nucleophosmin for cancer treatment: an update
por: Di Matteo, Adele, et al.
Publicado: (2016)

Nucleophosmin: from structure and function to disease development
por: Box, Joseph K., et al.
Publicado: (2016)

Nucleophosmin 1 Mutations in Acute Myeloid Leukemia
por: Zarka, Jabra, et al.
Publicado: (2020)

Chromatin localization of nucleophosmin organizes ribosome biogenesis
por: Ugolini, Ilaria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l2u5h5oakmovbciljijrdg8h70