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Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been defined as a unique subgroup in the new classification of myeloid neoplasm, and the AML patients with mutated NPM1 frequently present extramedullary infiltration, but how NPM1 mutants regulate this process remains elusive. In th...

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Detalles Bibliográficos
Autores principales:	Xian, Jingrong, Shao, Huiyuan, Chen, Xianchun, Zhang, Shuaishuai, Quan, Jing, Zou, Qin, Jin, Hongjun, Zhang, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737672/ https://www.ncbi.nlm.nih.gov/pubmed/26884713 http://dx.doi.org/10.7150/ijbs.13382

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