Development of a method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for studying the in vitro metabolism of phosphorothioate oligonucleotides

Ultra high performance liquid chromatography hyphenated with quadrupole time-of-flight mass spectrometry was used to determine the products of the in vitro metabolism of phosphorothioate oligonucleotides. These compounds may be used during antisense therapy as synthetic fragments of genes. For this...

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Detalles Bibliográficos
Autores principales: Studzińska, Sylwia, Rola, Rafał, Buszewski, Bogusław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737794/
https://www.ncbi.nlm.nih.gov/pubmed/26758600
http://dx.doi.org/10.1007/s00216-015-9266-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737794/
https://www.ncbi.nlm.nih.gov/pubmed/26758600
http://dx.doi.org/10.1007/s00216-015-9266-1

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