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Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model
BACKGROUND: Hair loss and hair growth is the subject of tremendous amount of research. OBJECTIVE: This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow (Dar-Al-Dawa Pharma),...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737838/ https://www.ncbi.nlm.nih.gov/pubmed/26848220 http://dx.doi.org/10.5021/ad.2016.28.1.65 |
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author | Orasan, Meda Sandra Bolfa, Pompei Coneac, Andrei Muresan, Adriana Mihu, Carmen |
author_facet | Orasan, Meda Sandra Bolfa, Pompei Coneac, Andrei Muresan, Adriana Mihu, Carmen |
author_sort | Orasan, Meda Sandra |
collection | PubMed |
description | BACKGROUND: Hair loss and hair growth is the subject of tremendous amount of research. OBJECTIVE: This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow (Dar-Al-Dawa Pharma), Aminexil, Dercos (Vichy Laboratoires), and Kerium, Anti-chute (La Roche-Posay). METHODS: Thirty-two adult female Wistar-Bratislava rats were assigned to 4 groups. Two rectangular areas (2×4 cm) were shaved on either sides of the mid dorsal line (left side - control; right side - test area). Group I was treated topically with 2% minoxidil, group II with Aminexil, and group III with Kerium. Each rat received 0.3 ml of substance applied topically to the shaved dorsal skin every day for 28 days. Rats in group IV served as sham controls receiving no treatment. Hair regrowth was evaluated by trichoscopy (with a dermatoscope), grown hair weight (from a surface area of 1 cm(2)), and histopathological examination for skin thickness, follicle count, and percentage of anagen induction (morphometric assessment). RESULTS: Treatment with 2% minoxidil significantly induced hair regrowth as assessed by trichoscopy, hair weight examination, and morphometric evaluation. Hair weight examination and morphometric assessment demonstrated the lowest hair growth effect with Aminexil among the tested products. Treatment with Kerium was found to significantly induce hair regrowth (p<0.05 as compared to the control group). CONCLUSION: Our study demonstrates that hair regrowth efficacy of products recommended for human use is not similar when tested on an animal model. |
format | Online Article Text |
id | pubmed-4737838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-47378382016-02-04 Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model Orasan, Meda Sandra Bolfa, Pompei Coneac, Andrei Muresan, Adriana Mihu, Carmen Ann Dermatol Original Article BACKGROUND: Hair loss and hair growth is the subject of tremendous amount of research. OBJECTIVE: This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow (Dar-Al-Dawa Pharma), Aminexil, Dercos (Vichy Laboratoires), and Kerium, Anti-chute (La Roche-Posay). METHODS: Thirty-two adult female Wistar-Bratislava rats were assigned to 4 groups. Two rectangular areas (2×4 cm) were shaved on either sides of the mid dorsal line (left side - control; right side - test area). Group I was treated topically with 2% minoxidil, group II with Aminexil, and group III with Kerium. Each rat received 0.3 ml of substance applied topically to the shaved dorsal skin every day for 28 days. Rats in group IV served as sham controls receiving no treatment. Hair regrowth was evaluated by trichoscopy (with a dermatoscope), grown hair weight (from a surface area of 1 cm(2)), and histopathological examination for skin thickness, follicle count, and percentage of anagen induction (morphometric assessment). RESULTS: Treatment with 2% minoxidil significantly induced hair regrowth as assessed by trichoscopy, hair weight examination, and morphometric evaluation. Hair weight examination and morphometric assessment demonstrated the lowest hair growth effect with Aminexil among the tested products. Treatment with Kerium was found to significantly induce hair regrowth (p<0.05 as compared to the control group). CONCLUSION: Our study demonstrates that hair regrowth efficacy of products recommended for human use is not similar when tested on an animal model. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2016-02 2016-01-28 /pmc/articles/PMC4737838/ /pubmed/26848220 http://dx.doi.org/10.5021/ad.2016.28.1.65 Text en Copyright © 2016 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Orasan, Meda Sandra Bolfa, Pompei Coneac, Andrei Muresan, Adriana Mihu, Carmen Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model |
title | Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model |
title_full | Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model |
title_fullStr | Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model |
title_full_unstemmed | Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model |
title_short | Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model |
title_sort | topical products for human hair regeneration: a comparative study on an animal model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737838/ https://www.ncbi.nlm.nih.gov/pubmed/26848220 http://dx.doi.org/10.5021/ad.2016.28.1.65 |
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