ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity

It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to s...

Descripción completa

Detalles Bibliográficos
Autores principales: Robinson, J. E., Paluch, J., Dickman, D. K., Joiner, W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737855/
https://www.ncbi.nlm.nih.gov/pubmed/26813350
http://dx.doi.org/10.1038/ncomms10512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737855/
https://www.ncbi.nlm.nih.gov/pubmed/26813350
http://dx.doi.org/10.1038/ncomms10512

Ejemplares similares