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ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737855/ https://www.ncbi.nlm.nih.gov/pubmed/26813350 http://dx.doi.org/10.1038/ncomms10512 |