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Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice
Balance and maintaining postural equilibrium are important during stationary and dynamic movements to prevent falls, particularly in older adults. While our sense of balance is influenced by vestibular, proprioceptive, and visual information, this study focuses primarily on the vestibular component...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737917/ https://www.ncbi.nlm.nih.gov/pubmed/26869921 http://dx.doi.org/10.3389/fnagi.2016.00012 |
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author | Tung, Victoria W. K. Burton, Thomas J. Quail, Stephanie L. Mathews, Miranda A. Camp, Aaron J. |
author_facet | Tung, Victoria W. K. Burton, Thomas J. Quail, Stephanie L. Mathews, Miranda A. Camp, Aaron J. |
author_sort | Tung, Victoria W. K. |
collection | PubMed |
description | Balance and maintaining postural equilibrium are important during stationary and dynamic movements to prevent falls, particularly in older adults. While our sense of balance is influenced by vestibular, proprioceptive, and visual information, this study focuses primarily on the vestibular component and its age-related effects on balance. C57Bl/6J mice of ages 1, 5–6, 8–9 and 27–28 months were tested using a combination of standard (such as grip strength and rotarod) and newly-developed behavioral tests (including balance beam and walking trajectory tests with a vestibular stimulus). In the current study, we confirm a decline in fore-limb grip strength and gross motor coordination as age increases. We also show that a vestibular stimulus of low frequency (2–3 Hz) and duration can lead to age-dependent changes in balance beam performance, which was evident by increases in latency to begin walking on the beam as well as the number of times hind-feet slip (FS) from the beam. Furthermore, aged mice (27–28 months) that received continuous access to a running wheel for 4 weeks did not improve when retested. Mice of ages 1, 10, 13 and 27–28 months were also tested for changes in walking trajectory as a result of the vestibular stimulus. While no linear relationship was observed between the changes in trajectory and age, 1-month-old mice were considerably less affected than mice of ages 10, 13 and 27–28 months. Conclusion: this study confirms there are age-related declines in grip strength and gross motor coordination. We also demonstrate age-dependent changes to finer motor abilities as a result of a low frequency and duration vestibular stimulus. These changes showed that while the ability to perform the balance beam task remained intact across all ages tested, behavioral changes in task performance were observed. |
format | Online Article Text |
id | pubmed-4737917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47379172016-02-11 Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice Tung, Victoria W. K. Burton, Thomas J. Quail, Stephanie L. Mathews, Miranda A. Camp, Aaron J. Front Aging Neurosci Neuroscience Balance and maintaining postural equilibrium are important during stationary and dynamic movements to prevent falls, particularly in older adults. While our sense of balance is influenced by vestibular, proprioceptive, and visual information, this study focuses primarily on the vestibular component and its age-related effects on balance. C57Bl/6J mice of ages 1, 5–6, 8–9 and 27–28 months were tested using a combination of standard (such as grip strength and rotarod) and newly-developed behavioral tests (including balance beam and walking trajectory tests with a vestibular stimulus). In the current study, we confirm a decline in fore-limb grip strength and gross motor coordination as age increases. We also show that a vestibular stimulus of low frequency (2–3 Hz) and duration can lead to age-dependent changes in balance beam performance, which was evident by increases in latency to begin walking on the beam as well as the number of times hind-feet slip (FS) from the beam. Furthermore, aged mice (27–28 months) that received continuous access to a running wheel for 4 weeks did not improve when retested. Mice of ages 1, 10, 13 and 27–28 months were also tested for changes in walking trajectory as a result of the vestibular stimulus. While no linear relationship was observed between the changes in trajectory and age, 1-month-old mice were considerably less affected than mice of ages 10, 13 and 27–28 months. Conclusion: this study confirms there are age-related declines in grip strength and gross motor coordination. We also demonstrate age-dependent changes to finer motor abilities as a result of a low frequency and duration vestibular stimulus. These changes showed that while the ability to perform the balance beam task remained intact across all ages tested, behavioral changes in task performance were observed. Frontiers Media S.A. 2016-02-03 /pmc/articles/PMC4737917/ /pubmed/26869921 http://dx.doi.org/10.3389/fnagi.2016.00012 Text en Copyright © 2016 Tung, Burton, Quail, Mathews and Camp. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tung, Victoria W. K. Burton, Thomas J. Quail, Stephanie L. Mathews, Miranda A. Camp, Aaron J. Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice |
title | Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice |
title_full | Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice |
title_fullStr | Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice |
title_full_unstemmed | Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice |
title_short | Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice |
title_sort | motor performance is impaired following vestibular stimulation in ageing mice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737917/ https://www.ncbi.nlm.nih.gov/pubmed/26869921 http://dx.doi.org/10.3389/fnagi.2016.00012 |
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