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Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment
The aims of this study were to 1) compare resting state functional connectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descending pain modulatory system (DPMS) between migraine without aura (MwoA) patients and healthy controls (HC), and 2) investigate how an effective treatmen...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738255/ https://www.ncbi.nlm.nih.gov/pubmed/26839078 http://dx.doi.org/10.1038/srep20298 |
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author | Li, Zhengjie Liu, Mailan Lan, Lei Zeng, Fang Makris, Nikos Liang, Yilin Guo, Taipin Wu, Feng Gao, Yujie Dong, Mingkai Yang, Jie Li, Ying Gong, Qiyong Liang, Fanrong Kong, Jian |
author_facet | Li, Zhengjie Liu, Mailan Lan, Lei Zeng, Fang Makris, Nikos Liang, Yilin Guo, Taipin Wu, Feng Gao, Yujie Dong, Mingkai Yang, Jie Li, Ying Gong, Qiyong Liang, Fanrong Kong, Jian |
author_sort | Li, Zhengjie |
collection | PubMed |
description | The aims of this study were to 1) compare resting state functional connectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descending pain modulatory system (DPMS) between migraine without aura (MwoA) patients and healthy controls (HC), and 2) investigate how an effective treatment can influence the PAG rs-fc in MwoA patients. One hundred MwoA patients and forty-six matched HC were recruited. Patients were randomized to verum acupuncture, sham acupuncture, and waiting list groups. Resting state fMRI data were collected and seed based functional connectivity analysis was applied. Compared with HC, MwoA patients showed reduced rs-fc between the PAG and rostral anterior cingulate cortex/medial prefrontal cortex (rACC/mPFC), key regions in the DPMS and other pain related brain regions. The reduced rs-fc between the PAG and rACC/mPFC was associated with increased migraine headache intensity at the baseline. After treatments, rs-fc between the PAG and the rACC in MwoA patients significantly increased. The changes of rs-fc among the PAG, rACC and ventral striatum were significantly associated with headache intensity improvement. Impairment of the DPMS is involved in the neural pathophysiology of migraines. Impaired DPMS in migraine patients can be normalized after effective treatment. |
format | Online Article Text |
id | pubmed-4738255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47382552016-02-09 Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment Li, Zhengjie Liu, Mailan Lan, Lei Zeng, Fang Makris, Nikos Liang, Yilin Guo, Taipin Wu, Feng Gao, Yujie Dong, Mingkai Yang, Jie Li, Ying Gong, Qiyong Liang, Fanrong Kong, Jian Sci Rep Article The aims of this study were to 1) compare resting state functional connectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descending pain modulatory system (DPMS) between migraine without aura (MwoA) patients and healthy controls (HC), and 2) investigate how an effective treatment can influence the PAG rs-fc in MwoA patients. One hundred MwoA patients and forty-six matched HC were recruited. Patients were randomized to verum acupuncture, sham acupuncture, and waiting list groups. Resting state fMRI data were collected and seed based functional connectivity analysis was applied. Compared with HC, MwoA patients showed reduced rs-fc between the PAG and rostral anterior cingulate cortex/medial prefrontal cortex (rACC/mPFC), key regions in the DPMS and other pain related brain regions. The reduced rs-fc between the PAG and rACC/mPFC was associated with increased migraine headache intensity at the baseline. After treatments, rs-fc between the PAG and the rACC in MwoA patients significantly increased. The changes of rs-fc among the PAG, rACC and ventral striatum were significantly associated with headache intensity improvement. Impairment of the DPMS is involved in the neural pathophysiology of migraines. Impaired DPMS in migraine patients can be normalized after effective treatment. Nature Publishing Group 2016-02-03 /pmc/articles/PMC4738255/ /pubmed/26839078 http://dx.doi.org/10.1038/srep20298 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Li, Zhengjie Liu, Mailan Lan, Lei Zeng, Fang Makris, Nikos Liang, Yilin Guo, Taipin Wu, Feng Gao, Yujie Dong, Mingkai Yang, Jie Li, Ying Gong, Qiyong Liang, Fanrong Kong, Jian Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
title | Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
title_full | Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
title_fullStr | Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
title_full_unstemmed | Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
title_short | Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
title_sort | altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738255/ https://www.ncbi.nlm.nih.gov/pubmed/26839078 http://dx.doi.org/10.1038/srep20298 |
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