Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system under continuous flow conditions in a serum-free defined medium utilizing a pumpless platform for 14 days. Computer simulations of the platform established flow rates and resultant shear stress within accepted...

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Detalles Bibliográficos
Autores principales: Oleaga, Carlota, Bernabini, Catia, Smith, Alec S.T., Srinivasan, Balaji, Jackson, Max, McLamb, William, Platt, Vivien, Bridges, Richard, Cai, Yunqing, Santhanam, Navaneetha, Berry, Bonnie, Najjar, Sarah, Akanda, Nesar, Guo, Xiufang, Martin, Candace, Ekman, Gail, Esch, Mandy B., Langer, Jessica, Ouedraogo, Gladys, Cotovio, Jose, Breton, Lionel, Shuler, Michael L., Hickman, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738272/
https://www.ncbi.nlm.nih.gov/pubmed/26837601
http://dx.doi.org/10.1038/srep20030

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