Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

Transthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD transgenic mice with only one copy of the TTR gene show increased brain and plasma Aβ levels when compared to AD mice with both copies of the gene, su...

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Detalles Bibliográficos
Autores principales: Alemi, Mobina, Gaiteiro, Cristiana, Ribeiro, Carlos Alexandre, Santos, Luís Miguel, Gomes, João Rodrigues, Oliveira, Sandra Marisa, Couraud, Pierre-Olivier, Weksler, Babette, Romero, Ignacio, Saraiva, Maria João, Cardoso, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738280/
https://www.ncbi.nlm.nih.gov/pubmed/26837706
http://dx.doi.org/10.1038/srep20164

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