Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients

Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA) pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine expression in macrophages, pivotal cells in RA aetiopathogenesis, which hints at specific circuits that regulate the...

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Detalles Bibliográficos
Autores principales: Ogando, Jesús, Tardáguila, Manuel, Díaz-Alderete, Andrea, Usategui, Alicia, Miranda-Ramos, Vanessa, Martínez-Herrera, Dannys Jorge, de la Fuente, Lorena, García-León, María J., Moreno, María C., Escudero, Sara, Cañete, Juan D., Toribio, María L., Cases, Ildefonso, Pascual-Montano, Alberto, Pablos, José Luis, Mañes, Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738320/
https://www.ncbi.nlm.nih.gov/pubmed/26838552
http://dx.doi.org/10.1038/srep20223

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