Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function

Bile acid (BA) metabolism is tightly controlled by nuclear receptor signaling to coordinate regulation of BA synthetic enzymes and transporters. Here we reveal a molecular cascade consisting of the antiapoptotic protein BCL2, nuclear receptor Shp, and long non-coding RNA (lncRNA) H19 to maintain BA...

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Detalles Bibliográficos
Autores principales: Zhang, Yuxia, Liu, Chune, Barbier, Olivier, Smalling, Rana, Tsuchiya, Hiroyuki, Lee, Sangmin, Delker, Don, Zou, An, Hagedorn, Curt H., Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738356/
https://www.ncbi.nlm.nih.gov/pubmed/26838806
http://dx.doi.org/10.1038/srep20559

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