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UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

The cellular defence protein Nrf2 is a mediator of oncogenesis in pancreatic ductal adenocarcinoma (PDAC) and other cancers. However, the control of Nrf2 expression and activity in cancer is not fully understood. We previously reported the absence of Keap1, a pivotal regulator of Nrf2, in ∼70% of PD...

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Detalles Bibliográficos
Autores principales:	Abu‐Alainin, Wafa, Gana, Thompson, Liloglou, Triantafillos, Olayanju, Adedamola, Barrera, Lawrence N, Ferguson, Robert, Campbell, Fiona, Andrews, Timothy, Goldring, Christopher, Kitteringham, Neil, Park, Brian K, Nedjadi, Taoufik, Schmid, Michael C, Slupsky, Joseph R, Greenhalf, William, Neoptolemos, John P, Costello, Eithne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738372/ https://www.ncbi.nlm.nih.gov/pubmed/26497117 http://dx.doi.org/10.1002/path.4665

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