Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

Proteolytic cleavage of the dynamin-like guanosine triphosphatase OPA1 in mitochondria is emerging as a central regulatory hub that determines mitochondrial morphology under stress and in disease. Stress-induced OPA1 processing by OMA1 triggersmitochondrial fragmentation, which is associated with mi...

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Detalles Bibliográficos
Autores principales: Korwitz, Anne, Merkwirth, Carsten, Richter-Dennerlein, Ricarda, Tröder, Simon E., Sprenger, Hans-Georg, Quirós, Pedro M., López-Otín, Carlos, Rugarli, Elena I., Langer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738383/
https://www.ncbi.nlm.nih.gov/pubmed/26783299
http://dx.doi.org/10.1083/jcb.201507022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738383/
https://www.ncbi.nlm.nih.gov/pubmed/26783299
http://dx.doi.org/10.1083/jcb.201507022

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