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Collective cell migration in development

During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migr...

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Detalles Bibliográficos
Autores principales: Scarpa, Elena, Mayor, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738384/
https://www.ncbi.nlm.nih.gov/pubmed/26783298
http://dx.doi.org/10.1083/jcb.201508047
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author Scarpa, Elena
Mayor, Roberto
author_facet Scarpa, Elena
Mayor, Roberto
author_sort Scarpa, Elena
collection PubMed
description During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migration. The molecular and biomechanical mechanisms underlying collective migration of developing tissues have been investigated in a variety of models, including border cell migration, tracheal branching, blood vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mesendoderm. Here we review recent advances in understanding collective migration in these developmental models, focusing on the interaction between cells and guidance cues presented by the microenvironment and on the role of cell–cell adhesion in mechanical and behavioral coupling of cells within the collective.
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spelling pubmed-47383842016-07-18 Collective cell migration in development Scarpa, Elena Mayor, Roberto J Cell Biol Reviews During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migration. The molecular and biomechanical mechanisms underlying collective migration of developing tissues have been investigated in a variety of models, including border cell migration, tracheal branching, blood vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mesendoderm. Here we review recent advances in understanding collective migration in these developmental models, focusing on the interaction between cells and guidance cues presented by the microenvironment and on the role of cell–cell adhesion in mechanical and behavioral coupling of cells within the collective. The Rockefeller University Press 2016-01-18 /pmc/articles/PMC4738384/ /pubmed/26783298 http://dx.doi.org/10.1083/jcb.201508047 Text en © 2016 Scarpa and Mayor This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Scarpa, Elena
Mayor, Roberto
Collective cell migration in development
title Collective cell migration in development
title_full Collective cell migration in development
title_fullStr Collective cell migration in development
title_full_unstemmed Collective cell migration in development
title_short Collective cell migration in development
title_sort collective cell migration in development
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738384/
https://www.ncbi.nlm.nih.gov/pubmed/26783298
http://dx.doi.org/10.1083/jcb.201508047
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