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Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus

Chronic hepatitis C virus infection is associated with significant morbidity and mortality, as a result of progression towards advanced natural course stages including cirrhosis and hepatocellular carcinoma. On the other hand, the SVR following successful therapy is generally associated with resolut...

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Autores principales: Voulgaris, Theodoros, Sevastianos, Vassilios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738722/
https://www.ncbi.nlm.nih.gov/pubmed/26885388
http://dx.doi.org/10.1155/2016/7629318
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author Voulgaris, Theodoros
Sevastianos, Vassilios A.
author_facet Voulgaris, Theodoros
Sevastianos, Vassilios A.
author_sort Voulgaris, Theodoros
collection PubMed
description Chronic hepatitis C virus infection is associated with significant morbidity and mortality, as a result of progression towards advanced natural course stages including cirrhosis and hepatocellular carcinoma. On the other hand, the SVR following successful therapy is generally associated with resolution of liver disease in patients without cirrhosis. Patients with cirrhosis remain at risk of life-threatening complications despite the fact that hepatic fibrosis may regress and the risk of complications such as hepatic failure and portal hypertension is reduced. Furthermore, recent data suggest that the risk of HCC and all-cause mortality is significantly reduced, but not eliminated, in cirrhotic patients who clear HCV compared to untreated patients and nonsustained virological responders. Data derived from studies have demonstrated a strong link between HCV infection and the atherogenic process. Subsequently HCV seems to represent a strong, independent risk factor for coronary heart disease, carotid atherosclerosis, stroke, and, ultimately, CVD related mortality. The advent of new direct acting antiviral therapy has dramatically increased the sustained virological response rates of hepatitis C infection. In this scenario, the cardiovascular risk has emerged and represents a major concern after the eradication of the virus which may influence the life expectancy and the quality of patients' life.
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spelling pubmed-47387222016-02-16 Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus Voulgaris, Theodoros Sevastianos, Vassilios A. Hepat Res Treat Review Article Chronic hepatitis C virus infection is associated with significant morbidity and mortality, as a result of progression towards advanced natural course stages including cirrhosis and hepatocellular carcinoma. On the other hand, the SVR following successful therapy is generally associated with resolution of liver disease in patients without cirrhosis. Patients with cirrhosis remain at risk of life-threatening complications despite the fact that hepatic fibrosis may regress and the risk of complications such as hepatic failure and portal hypertension is reduced. Furthermore, recent data suggest that the risk of HCC and all-cause mortality is significantly reduced, but not eliminated, in cirrhotic patients who clear HCV compared to untreated patients and nonsustained virological responders. Data derived from studies have demonstrated a strong link between HCV infection and the atherogenic process. Subsequently HCV seems to represent a strong, independent risk factor for coronary heart disease, carotid atherosclerosis, stroke, and, ultimately, CVD related mortality. The advent of new direct acting antiviral therapy has dramatically increased the sustained virological response rates of hepatitis C infection. In this scenario, the cardiovascular risk has emerged and represents a major concern after the eradication of the virus which may influence the life expectancy and the quality of patients' life. Hindawi Publishing Corporation 2016 2016-01-13 /pmc/articles/PMC4738722/ /pubmed/26885388 http://dx.doi.org/10.1155/2016/7629318 Text en Copyright © 2016 T. Voulgaris and V. A. Sevastianos. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Voulgaris, Theodoros
Sevastianos, Vassilios A.
Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus
title Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus
title_full Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus
title_fullStr Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus
title_full_unstemmed Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus
title_short Atherosclerosis as Extrahepatic Manifestation of Chronic Infection with Hepatitis C Virus
title_sort atherosclerosis as extrahepatic manifestation of chronic infection with hepatitis c virus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738722/
https://www.ncbi.nlm.nih.gov/pubmed/26885388
http://dx.doi.org/10.1155/2016/7629318
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