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Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
OBJECTIVES: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dys...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Medicina Intensiva Brasileira -
AMIB
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738824/ https://www.ncbi.nlm.nih.gov/pubmed/26761476 http://dx.doi.org/10.5935/0103-507X.20150063 |
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author | Alves, Fernanda Sampaio Freitas, Flavio Geraldo Resende Bafi, Antonio Tonete Azevedo, Luciano Cesar Pontes Machado, Flavia Ribeiro |
author_facet | Alves, Fernanda Sampaio Freitas, Flavio Geraldo Resende Bafi, Antonio Tonete Azevedo, Luciano Cesar Pontes Machado, Flavia Ribeiro |
author_sort | Alves, Fernanda Sampaio |
collection | PubMed |
description | OBJECTIVES: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dysfunction. METHODS: This case-control, prospective, observational study involved patients aged > 18 years with severe sepsis or septic shock paired with a control group. Serum vitamin D concentrations were measured at inclusion (D0) and on the seventh day after inclusion (D7). Severe deficiency was defined as vitamin D levels < 10ng/ml, deficiency as levels between 10 and 20ng/ml, insufficiency as levels between 20 and 30ng/ml, and sufficiency as levels ≥ 30ng/mL. We considered a change to a higher ranking, together with a 50% increase in the absolute concentration, to represent an improvement. RESULTS: We included 51 patients (26 with septic shock and 25 controls). The prevalence of vitamin D concentration ≤ 30ng/ml was 98%. There was no correlation between the serum concentration of vitamin D at D0 and the SOFA score at D0 or D7 either in the general population or in the group with septic shock. Patients with improvement in vitamin D deficiency had an improved SOFA score at D7 (p = 0.013). CONCLUSION: In the population studied, patients with septic shock showed improvement in the serum concentrations of vitamin D on the seventh day compared with the controls. We also found a correlation between higher vitamin D concentrations and a greater decrease in the severity of organ dysfunction. |
format | Online Article Text |
id | pubmed-4738824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Associação de Medicina Intensiva Brasileira -
AMIB |
record_format | MEDLINE/PubMed |
spelling | pubmed-47388242016-02-11 Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock Alves, Fernanda Sampaio Freitas, Flavio Geraldo Resende Bafi, Antonio Tonete Azevedo, Luciano Cesar Pontes Machado, Flavia Ribeiro Rev Bras Ter Intensiva Original Article OBJECTIVES: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dysfunction. METHODS: This case-control, prospective, observational study involved patients aged > 18 years with severe sepsis or septic shock paired with a control group. Serum vitamin D concentrations were measured at inclusion (D0) and on the seventh day after inclusion (D7). Severe deficiency was defined as vitamin D levels < 10ng/ml, deficiency as levels between 10 and 20ng/ml, insufficiency as levels between 20 and 30ng/ml, and sufficiency as levels ≥ 30ng/mL. We considered a change to a higher ranking, together with a 50% increase in the absolute concentration, to represent an improvement. RESULTS: We included 51 patients (26 with septic shock and 25 controls). The prevalence of vitamin D concentration ≤ 30ng/ml was 98%. There was no correlation between the serum concentration of vitamin D at D0 and the SOFA score at D0 or D7 either in the general population or in the group with septic shock. Patients with improvement in vitamin D deficiency had an improved SOFA score at D7 (p = 0.013). CONCLUSION: In the population studied, patients with septic shock showed improvement in the serum concentrations of vitamin D on the seventh day compared with the controls. We also found a correlation between higher vitamin D concentrations and a greater decrease in the severity of organ dysfunction. Associação de Medicina Intensiva Brasileira - AMIB 2015 /pmc/articles/PMC4738824/ /pubmed/26761476 http://dx.doi.org/10.5935/0103-507X.20150063 Text en http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Alves, Fernanda Sampaio Freitas, Flavio Geraldo Resende Bafi, Antonio Tonete Azevedo, Luciano Cesar Pontes Machado, Flavia Ribeiro Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock |
title | Serum concentrations of vitamin D and organ dysfunction in
patients with severe sepsis and septic shock |
title_full | Serum concentrations of vitamin D and organ dysfunction in
patients with severe sepsis and septic shock |
title_fullStr | Serum concentrations of vitamin D and organ dysfunction in
patients with severe sepsis and septic shock |
title_full_unstemmed | Serum concentrations of vitamin D and organ dysfunction in
patients with severe sepsis and septic shock |
title_short | Serum concentrations of vitamin D and organ dysfunction in
patients with severe sepsis and septic shock |
title_sort | serum concentrations of vitamin d and organ dysfunction in
patients with severe sepsis and septic shock |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738824/ https://www.ncbi.nlm.nih.gov/pubmed/26761476 http://dx.doi.org/10.5935/0103-507X.20150063 |
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