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Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock

OBJECTIVES: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dys...

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Autores principales: Alves, Fernanda Sampaio, Freitas, Flavio Geraldo Resende, Bafi, Antonio Tonete, Azevedo, Luciano Cesar Pontes, Machado, Flavia Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Medicina Intensiva Brasileira - AMIB 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738824/
https://www.ncbi.nlm.nih.gov/pubmed/26761476
http://dx.doi.org/10.5935/0103-507X.20150063
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author Alves, Fernanda Sampaio
Freitas, Flavio Geraldo Resende
Bafi, Antonio Tonete
Azevedo, Luciano Cesar Pontes
Machado, Flavia Ribeiro
author_facet Alves, Fernanda Sampaio
Freitas, Flavio Geraldo Resende
Bafi, Antonio Tonete
Azevedo, Luciano Cesar Pontes
Machado, Flavia Ribeiro
author_sort Alves, Fernanda Sampaio
collection PubMed
description OBJECTIVES: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dysfunction. METHODS: This case-control, prospective, observational study involved patients aged > 18 years with severe sepsis or septic shock paired with a control group. Serum vitamin D concentrations were measured at inclusion (D0) and on the seventh day after inclusion (D7). Severe deficiency was defined as vitamin D levels < 10ng/ml, deficiency as levels between 10 and 20ng/ml, insufficiency as levels between 20 and 30ng/ml, and sufficiency as levels ≥ 30ng/mL. We considered a change to a higher ranking, together with a 50% increase in the absolute concentration, to represent an improvement. RESULTS: We included 51 patients (26 with septic shock and 25 controls). The prevalence of vitamin D concentration ≤ 30ng/ml was 98%. There was no correlation between the serum concentration of vitamin D at D0 and the SOFA score at D0 or D7 either in the general population or in the group with septic shock. Patients with improvement in vitamin D deficiency had an improved SOFA score at D7 (p = 0.013). CONCLUSION: In the population studied, patients with septic shock showed improvement in the serum concentrations of vitamin D on the seventh day compared with the controls. We also found a correlation between higher vitamin D concentrations and a greater decrease in the severity of organ dysfunction.
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spelling pubmed-47388242016-02-11 Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock Alves, Fernanda Sampaio Freitas, Flavio Geraldo Resende Bafi, Antonio Tonete Azevedo, Luciano Cesar Pontes Machado, Flavia Ribeiro Rev Bras Ter Intensiva Original Article OBJECTIVES: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dysfunction. METHODS: This case-control, prospective, observational study involved patients aged > 18 years with severe sepsis or septic shock paired with a control group. Serum vitamin D concentrations were measured at inclusion (D0) and on the seventh day after inclusion (D7). Severe deficiency was defined as vitamin D levels < 10ng/ml, deficiency as levels between 10 and 20ng/ml, insufficiency as levels between 20 and 30ng/ml, and sufficiency as levels ≥ 30ng/mL. We considered a change to a higher ranking, together with a 50% increase in the absolute concentration, to represent an improvement. RESULTS: We included 51 patients (26 with septic shock and 25 controls). The prevalence of vitamin D concentration ≤ 30ng/ml was 98%. There was no correlation between the serum concentration of vitamin D at D0 and the SOFA score at D0 or D7 either in the general population or in the group with septic shock. Patients with improvement in vitamin D deficiency had an improved SOFA score at D7 (p = 0.013). CONCLUSION: In the population studied, patients with septic shock showed improvement in the serum concentrations of vitamin D on the seventh day compared with the controls. We also found a correlation between higher vitamin D concentrations and a greater decrease in the severity of organ dysfunction. Associação de Medicina Intensiva Brasileira - AMIB 2015 /pmc/articles/PMC4738824/ /pubmed/26761476 http://dx.doi.org/10.5935/0103-507X.20150063 Text en http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alves, Fernanda Sampaio
Freitas, Flavio Geraldo Resende
Bafi, Antonio Tonete
Azevedo, Luciano Cesar Pontes
Machado, Flavia Ribeiro
Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
title Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
title_full Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
title_fullStr Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
title_full_unstemmed Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
title_short Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock
title_sort serum concentrations of vitamin d and organ dysfunction in patients with severe sepsis and septic shock
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738824/
https://www.ncbi.nlm.nih.gov/pubmed/26761476
http://dx.doi.org/10.5935/0103-507X.20150063
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