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Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies

We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic...

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Autores principales: Sawicka-Gutaj, Nadia, Zybek-Kocik, Ariadna, Klimowicz, Aleksandra, Kloska, Michał, Mańkowska-Wierzbicka, Dorota, Sowiński, Jerzy, Ruchała, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739229/
https://www.ncbi.nlm.nih.gov/pubmed/26884761
http://dx.doi.org/10.1155/2016/7402469
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author Sawicka-Gutaj, Nadia
Zybek-Kocik, Ariadna
Klimowicz, Aleksandra
Kloska, Michał
Mańkowska-Wierzbicka, Dorota
Sowiński, Jerzy
Ruchała, Marek
author_facet Sawicka-Gutaj, Nadia
Zybek-Kocik, Ariadna
Klimowicz, Aleksandra
Kloska, Michał
Mańkowska-Wierzbicka, Dorota
Sowiński, Jerzy
Ruchała, Marek
author_sort Sawicka-Gutaj, Nadia
collection PubMed
description We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis. The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1. The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level. Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels. The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p = 0.0001). Simple linear regression analysis revealed that visfatin serum concentration was significantly associated with autoimmunity (β = 0.1014; p = 0.003), FT4 (β = 0.05412; p = 0.048), FT3 (β = 0.05242; p = 0.038), and TPOAb (β = 0.0002; p = 0.0025), and the relationships were further confirmed in the multivariate regression analysis.
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spelling pubmed-47392292016-02-16 Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies Sawicka-Gutaj, Nadia Zybek-Kocik, Ariadna Klimowicz, Aleksandra Kloska, Michał Mańkowska-Wierzbicka, Dorota Sowiński, Jerzy Ruchała, Marek Int J Endocrinol Clinical Study We hypothesized that regulation of visfatin in hypothyroidism might be altered by coexisting chronic autoimmune thyroiditis. This is a prospective case-control study of 118 subjects. The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis. The nonautoimmune study group (TT) consisted of 40 patients thyroidectomized due to the differentiated thyroid cancer staged pT1. The control group comprised 39 healthy volunteers adjusted for age, sex, and BMI with normal thyroid function and negative thyroid antibodies. Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level. Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels. The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p = 0.0001). Simple linear regression analysis revealed that visfatin serum concentration was significantly associated with autoimmunity (β = 0.1014; p = 0.003), FT4 (β = 0.05412; p = 0.048), FT3 (β = 0.05242; p = 0.038), and TPOAb (β = 0.0002; p = 0.0025), and the relationships were further confirmed in the multivariate regression analysis. Hindawi Publishing Corporation 2016 2016-01-17 /pmc/articles/PMC4739229/ /pubmed/26884761 http://dx.doi.org/10.1155/2016/7402469 Text en Copyright © 2016 Nadia Sawicka-Gutaj et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Sawicka-Gutaj, Nadia
Zybek-Kocik, Ariadna
Klimowicz, Aleksandra
Kloska, Michał
Mańkowska-Wierzbicka, Dorota
Sowiński, Jerzy
Ruchała, Marek
Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
title Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
title_full Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
title_fullStr Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
title_full_unstemmed Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
title_short Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
title_sort circulating visfatin in hypothyroidism is associated with free thyroid hormones and antithyroperoxidase antibodies
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739229/
https://www.ncbi.nlm.nih.gov/pubmed/26884761
http://dx.doi.org/10.1155/2016/7402469
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