α-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation

BACKGROUND: The pathological hallmark of Parkinson’s disease is the deposition of cytoplasmic neuronal inclusions termed Lewy bodies. The major component of Lewy bodies is amyloid fibrils of α-synuclein. To investigate what causes α-synuclein aggregation is essential to understand its pathological r...

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Detalles Bibliográficos
Autores principales: Bai, Jia, Zhang, Zeting, Liu, Maili, Li, Conggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739322/
https://www.ncbi.nlm.nih.gov/pubmed/26843956
http://dx.doi.org/10.1186/s13628-016-0026-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739322/
https://www.ncbi.nlm.nih.gov/pubmed/26843956
http://dx.doi.org/10.1186/s13628-016-0026-1

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