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α-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation
BACKGROUND: The pathological hallmark of Parkinson’s disease is the deposition of cytoplasmic neuronal inclusions termed Lewy bodies. The major component of Lewy bodies is amyloid fibrils of α-synuclein. To investigate what causes α-synuclein aggregation is essential to understand its pathological r...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739322/ https://www.ncbi.nlm.nih.gov/pubmed/26843956 http://dx.doi.org/10.1186/s13628-016-0026-1 |