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Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways

BACKGROUND: Poorly soluble cobalt (II, III) oxide particles (Co(3)O(4)P) are believed to induce in vitro cytotoxic effects via a Trojan-horse mechanism. Once internalized into lysosomal and acidic intracellular compartments, Co(3)O(4)P slowly release a low amount of cobalt ions (Co(2+)) that impair...

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Detalles Bibliográficos
Autores principales:	Uboldi, Chiara, Orsière, Thierry, Darolles, Carine, Aloin, Valérie, Tassistro, Virginie, George, Isabelle, Malard, Véronique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739324/ https://www.ncbi.nlm.nih.gov/pubmed/26843362 http://dx.doi.org/10.1186/s12989-016-0118-8

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