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High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia

Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective...

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Autores principales: Grisé, Kenneth N., Olver, T. Dylan, McDonald, Matthew W., Dey, Adwitia, Jiang, Mao, Lacefield, James C., Shoemaker, J. Kevin, Noble, Earl G., Melling, C. W. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739461/
https://www.ncbi.nlm.nih.gov/pubmed/26885531
http://dx.doi.org/10.1155/2016/8164518
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author Grisé, Kenneth N.
Olver, T. Dylan
McDonald, Matthew W.
Dey, Adwitia
Jiang, Mao
Lacefield, James C.
Shoemaker, J. Kevin
Noble, Earl G.
Melling, C. W. James
author_facet Grisé, Kenneth N.
Olver, T. Dylan
McDonald, Matthew W.
Dey, Adwitia
Jiang, Mao
Lacefield, James C.
Shoemaker, J. Kevin
Noble, Earl G.
Melling, C. W. James
author_sort Grisé, Kenneth N.
collection PubMed
description Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM.
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spelling pubmed-47394612016-02-16 High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia Grisé, Kenneth N. Olver, T. Dylan McDonald, Matthew W. Dey, Adwitia Jiang, Mao Lacefield, James C. Shoemaker, J. Kevin Noble, Earl G. Melling, C. W. James J Diabetes Res Research Article Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM. Hindawi Publishing Corporation 2016 2016-01-18 /pmc/articles/PMC4739461/ /pubmed/26885531 http://dx.doi.org/10.1155/2016/8164518 Text en Copyright © 2016 Kenneth N. Grisé et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grisé, Kenneth N.
Olver, T. Dylan
McDonald, Matthew W.
Dey, Adwitia
Jiang, Mao
Lacefield, James C.
Shoemaker, J. Kevin
Noble, Earl G.
Melling, C. W. James
High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
title High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
title_full High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
title_fullStr High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
title_full_unstemmed High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
title_short High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
title_sort high intensity aerobic exercise training improves deficits of cardiovascular autonomic function in a rat model of type 1 diabetes mellitus with moderate hyperglycemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739461/
https://www.ncbi.nlm.nih.gov/pubmed/26885531
http://dx.doi.org/10.1155/2016/8164518
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