Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

[Image: see text] Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the GPI anchor pathway, Gwt1, has generated interest in the expl...

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Detalles Bibliográficos
Autores principales: Mann, Paul A., McLellan, Catherine A., Koseoglu, Sandra, Si, Qian, Kuzmin, Elena, Flattery, Amy, Harris, Guy, Sher, Xinwei, Murgolo, Nicholas, Wang, Hao, Devito, Kristine, de Pedro, Nuria, Genilloud, Olga, Kahn, Jennifer Nielsen, Jiang, Bo, Costanzo, Michael, Boone, Charlie, Garlisi, Charles G., Lindquist, Susan, Roemer, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739577/
https://www.ncbi.nlm.nih.gov/pubmed/26878058
http://dx.doi.org/10.1021/id5000212

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