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Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair
Articular cartilage has poor capability for repair following trauma or degenerative pathology due to avascular property, low cell density and migratory ability. Discovery of novel therapeutic approaches for articular cartilage repair remains a significant clinical need. Hypoxia is a hallmark for car...
Autores principales: | Wang, Pengzhen, Zhang, Fengjie, He, Qiling, Wang, Jianqi, Shiu, Hoi Ting, Shu, Yinglan, Tsang, Wing Pui, Liang, Shuang, Zhao, Kai, Wan, Chao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739592/ https://www.ncbi.nlm.nih.gov/pubmed/26841115 http://dx.doi.org/10.1371/journal.pone.0148372 |
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