Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis. IAPP is innocuous under homeostatic conditions but i...

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Detalles Bibliográficos
Autores principales: Rulifson, Ingrid C., Cao, Ping, Miao, Li, Kopecky, David, Huang, Linda, White, Ryan D., Samayoa, Kim, Gardner, Jonitha, Wu, Xiaosu, Chen, Kui, Tsuruda, Trace, Homann, Oliver, Baribault, Helene, Yamane, Harvey, Carlson, Tim, Wiltzius, Jed, Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739698/
https://www.ncbi.nlm.nih.gov/pubmed/26840340
http://dx.doi.org/10.1371/journal.pone.0147254

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