Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression

The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects. Using RNA-seq, we evaluated targeted and neighboring gene expression in tissues from 44 homoz...

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Detalles Bibliográficos
Autores principales: West, David B., Engelhard, Eric K., Adkisson, Michael, Nava, A. J., Kirov, Julia V., Cipollone, Andreanna, Willis, Brandon, Rapp, Jared, de Jong, Pieter J., Lloyd, Kent C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739719/
https://www.ncbi.nlm.nih.gov/pubmed/26839965
http://dx.doi.org/10.1371/journal.pgen.1005691

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