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Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary areas, but mechanisms influencing higher orde...

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Detalles Bibliográficos
Autores principales: Zembrzycki, Andreas, Stocker, Adam M, Leingärtner, Axel, Sahara, Setsuko, Chou, Shen-Ju, Kalatsky, Valery, May, Scott R, Stryker, Michael P, O'Leary, Dennis DM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739755/
https://www.ncbi.nlm.nih.gov/pubmed/26705332
http://dx.doi.org/10.7554/eLife.11416
Descripción
Sumario:In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary areas, but mechanisms influencing higher order area properties are unknown. By exploiting gain-of and loss-of function mouse models of the transcription factor Emx2, we have generated bi-directional changes in primary visual cortex size in vivo and have used it as a model to show a novel and prominent function for genetic mechanisms regulating primary visual area size and also proportionally dictating the sizes of surrounding higher order visual areas. This finding redefines the role for intrinsic genetic mechanisms to concomitantly specify and scale primary and related higher order sensory areas in a linear fashion. DOI: http://dx.doi.org/10.7554/eLife.11416.001