Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial cells do not activate an ATM-or ATR-dependent DNA damage response (DDR), but accumulate oxidative-stress-induced DNA single-strand breaks (SSBs)...

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Detalles Bibliográficos
Autores principales: Nassour, Joe, Martien, Sébastien, Martin, Nathalie, Deruy, Emeric, Tomellini, Elisa, Malaquin, Nicolas, Bouali, Fatima, Sabatier, Laure, Wernert, Nicolas, Pinte, Sébastien, Gilson, Eric, Pourtier, Albin, Pluquet, Olivier, Abbadie, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740115/
https://www.ncbi.nlm.nih.gov/pubmed/26822533
http://dx.doi.org/10.1038/ncomms10399

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