Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

Non-CG methylation is an unexplored epigenetic hallmark of pluripotent stem cells. Here we report that a reduction in non-CG methylation is associated with impaired differentiation capacity into endodermal lineages. Genome-wide analysis of 2,670 non-CG sites in a discovery cohort of 25 phenotyped hu...

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Detalles Bibliográficos
Autores principales: Butcher, Lee M., Ito, Mitsuteru, Brimpari, Minodora, Morris, Tiffany J., Soares, Filipa A. C., Ährlund-Richter, Lars, Carey, Nessa, Vallier, Ludovic, Ferguson-Smith, Anne C., Beck, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740175/
https://www.ncbi.nlm.nih.gov/pubmed/26822956
http://dx.doi.org/10.1038/ncomms10458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740175/
https://www.ncbi.nlm.nih.gov/pubmed/26822956
http://dx.doi.org/10.1038/ncomms10458

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