Blocking the ZZ Domain of Sequestosome1/p62 Suppresses Myeloma Growth and Osteoclast Formation In Vitro and Induces Dramatic Bone Formation in Myeloma-Bearing Bones In Vivo

We reported that p62 (sequestosome 1) serves as a signaling hub in bone marrow stromal cells (BMSC) for the formation of signaling complexes, including NFκB, p38MAPK, and JNK, that are involved in the increased osteoclastogenesis and multiple myeloma (MM) cell growth induced by BMSC that are key con...

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Detalles Bibliográficos
Autores principales: Teramachi, Jumpei, Silbermann, Rebecca, Yang, Peng, Zhao, Wei, Mohammad, Khalid S., Guo, Jianxia, Anderson, Judith L., Zhou, Dan, Feng, Rentian, Myint, Kyaw-Zeyar, Maertz, Nathan, Beumer, Jan H., Eiseman, Julie L., Windle, Jolene J., Xie, Xiang-Qun, Roodman, G. David, Kurihara, Noriyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740189/
https://www.ncbi.nlm.nih.gov/pubmed/26286116
http://dx.doi.org/10.1038/leu.2015.229

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