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A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway
Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) and 2 (PHB2) are pan-genotypic HCV entry factors functioning at a post-binding...
Autores principales: | Liu, Shufeng, Wang, Wenyu, Brown, Lauren E., Qiu, Chao, Lajkiewicz, Neil, Zhao, Ting, Zhou, Jianhua, Porco, John A., Wang, Tony T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740292/ https://www.ncbi.nlm.nih.gov/pubmed/26870784 http://dx.doi.org/10.1016/j.ebiom.2015.09.018 |
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