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Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperi...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740298/ https://www.ncbi.nlm.nih.gov/pubmed/26870797 http://dx.doi.org/10.1016/j.ebiom.2015.09.044 |
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author | Cao, Huang-Ming Ye, Xiao-Ping Ma, Jun-Hua Jiang, He Li, Sheng-Xian Li, Rong-Ying Li, Xue-Song Guo, Cui-Cui Wang, Zhi-Quan Zhan, Ming Zuo, Chun-Lin Pan, Chun-Ming Zhao, Shuang-Xia Zheng, Cui-Xia Song, Huai-Dong |
author_facet | Cao, Huang-Ming Ye, Xiao-Ping Ma, Jun-Hua Jiang, He Li, Sheng-Xian Li, Rong-Ying Li, Xue-Song Guo, Cui-Cui Wang, Zhi-Quan Zhan, Ming Zuo, Chun-Lin Pan, Chun-Ming Zhao, Shuang-Xia Zheng, Cui-Xia Song, Huai-Dong |
author_sort | Cao, Huang-Ming |
collection | PubMed |
description | Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice. Furthermore, the expression of interleukin (IL)-1β and IL-6 was up-regulated in the hypothalamus by mimecan-MBP, as well as in N9 microglia cells by recombinant mouse mimecan. Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus. |
format | Online Article Text |
id | pubmed-4740298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47402982016-02-11 Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling Cao, Huang-Ming Ye, Xiao-Ping Ma, Jun-Hua Jiang, He Li, Sheng-Xian Li, Rong-Ying Li, Xue-Song Guo, Cui-Cui Wang, Zhi-Quan Zhan, Ming Zuo, Chun-Lin Pan, Chun-Ming Zhao, Shuang-Xia Zheng, Cui-Xia Song, Huai-Dong EBioMedicine Research Article Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice. Furthermore, the expression of interleukin (IL)-1β and IL-6 was up-regulated in the hypothalamus by mimecan-MBP, as well as in N9 microglia cells by recombinant mouse mimecan. Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus. Elsevier 2015-09-28 /pmc/articles/PMC4740298/ /pubmed/26870797 http://dx.doi.org/10.1016/j.ebiom.2015.09.044 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Cao, Huang-Ming Ye, Xiao-Ping Ma, Jun-Hua Jiang, He Li, Sheng-Xian Li, Rong-Ying Li, Xue-Song Guo, Cui-Cui Wang, Zhi-Quan Zhan, Ming Zuo, Chun-Lin Pan, Chun-Ming Zhao, Shuang-Xia Zheng, Cui-Xia Song, Huai-Dong Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling |
title | Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling |
title_full | Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling |
title_fullStr | Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling |
title_full_unstemmed | Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling |
title_short | Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling |
title_sort | mimecan, a hormone abundantly expressed in adipose tissue, reduced food intake independently of leptin signaling |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740298/ https://www.ncbi.nlm.nih.gov/pubmed/26870797 http://dx.doi.org/10.1016/j.ebiom.2015.09.044 |
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