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Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling

Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperi...

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Autores principales: Cao, Huang-Ming, Ye, Xiao-Ping, Ma, Jun-Hua, Jiang, He, Li, Sheng-Xian, Li, Rong-Ying, Li, Xue-Song, Guo, Cui-Cui, Wang, Zhi-Quan, Zhan, Ming, Zuo, Chun-Lin, Pan, Chun-Ming, Zhao, Shuang-Xia, Zheng, Cui-Xia, Song, Huai-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740298/
https://www.ncbi.nlm.nih.gov/pubmed/26870797
http://dx.doi.org/10.1016/j.ebiom.2015.09.044
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author Cao, Huang-Ming
Ye, Xiao-Ping
Ma, Jun-Hua
Jiang, He
Li, Sheng-Xian
Li, Rong-Ying
Li, Xue-Song
Guo, Cui-Cui
Wang, Zhi-Quan
Zhan, Ming
Zuo, Chun-Lin
Pan, Chun-Ming
Zhao, Shuang-Xia
Zheng, Cui-Xia
Song, Huai-Dong
author_facet Cao, Huang-Ming
Ye, Xiao-Ping
Ma, Jun-Hua
Jiang, He
Li, Sheng-Xian
Li, Rong-Ying
Li, Xue-Song
Guo, Cui-Cui
Wang, Zhi-Quan
Zhan, Ming
Zuo, Chun-Lin
Pan, Chun-Ming
Zhao, Shuang-Xia
Zheng, Cui-Xia
Song, Huai-Dong
author_sort Cao, Huang-Ming
collection PubMed
description Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice. Furthermore, the expression of interleukin (IL)-1β and IL-6 was up-regulated in the hypothalamus by mimecan-MBP, as well as in N9 microglia cells by recombinant mouse mimecan. Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus.
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spelling pubmed-47402982016-02-11 Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling Cao, Huang-Ming Ye, Xiao-Ping Ma, Jun-Hua Jiang, He Li, Sheng-Xian Li, Rong-Ying Li, Xue-Song Guo, Cui-Cui Wang, Zhi-Quan Zhan, Ming Zuo, Chun-Lin Pan, Chun-Ming Zhao, Shuang-Xia Zheng, Cui-Xia Song, Huai-Dong EBioMedicine Research Article Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice. Furthermore, the expression of interleukin (IL)-1β and IL-6 was up-regulated in the hypothalamus by mimecan-MBP, as well as in N9 microglia cells by recombinant mouse mimecan. Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus. Elsevier 2015-09-28 /pmc/articles/PMC4740298/ /pubmed/26870797 http://dx.doi.org/10.1016/j.ebiom.2015.09.044 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Cao, Huang-Ming
Ye, Xiao-Ping
Ma, Jun-Hua
Jiang, He
Li, Sheng-Xian
Li, Rong-Ying
Li, Xue-Song
Guo, Cui-Cui
Wang, Zhi-Quan
Zhan, Ming
Zuo, Chun-Lin
Pan, Chun-Ming
Zhao, Shuang-Xia
Zheng, Cui-Xia
Song, Huai-Dong
Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
title Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
title_full Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
title_fullStr Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
title_full_unstemmed Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
title_short Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling
title_sort mimecan, a hormone abundantly expressed in adipose tissue, reduced food intake independently of leptin signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740298/
https://www.ncbi.nlm.nih.gov/pubmed/26870797
http://dx.doi.org/10.1016/j.ebiom.2015.09.044
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