Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium. Because red blood cells (RBCs) are less deformable in diabetes, we explored an original concept linking decreased RBC deformability to RBC ascorbate and hyperglycemia. We characterized ascorbate concentrations...

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Detalles Bibliográficos
Autores principales: Tu, Hongbin, Li, Hongyan, Wang, Yu, Niyyati, Mahtab, Wang, Yaohui, Leshin, Jonathan, Levine, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740302/
https://www.ncbi.nlm.nih.gov/pubmed/26870799
http://dx.doi.org/10.1016/j.ebiom.2015.09.049

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