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BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries

BACKGROUND: Intimal hyperplasia is a common cause of many vasculopathies. There has been a recent surge of interest in the bromo and extra-terminal (BET) epigenetic “readers” including BRD4 since the serendipitous discovery of JQ1(+), an inhibitor specific to the seemingly undruggable BET bromodomai...

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Detalles Bibliográficos
Autores principales:	Wang, Bowen, Zhang, Mengxue, Takayama, Toshio, Shi, Xudong, Roenneburg, Drew Alan, Craig Kent, K., Guo, Lian-Wang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740308/ https://www.ncbi.nlm.nih.gov/pubmed/26870791 http://dx.doi.org/10.1016/j.ebiom.2015.09.045

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