Cargando…

A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan

BACKGROUND: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the preval...

Descripción completa

Detalles Bibliográficos
Autores principales: Inagaki, Yuki, Oshiro, Yukio, Tanaka, Tomohiro, Yoshizumi, Tomoharu, Okajima, Hideaki, Ishiyama, Kohei, Nakanishi, Chikashi, Hidaka, Masaaki, Wada, Hiroshi, Hibi, Taizo, Takagi, Kosei, Honda, Masaki, Kuramitsu, Kaori, Tanaka, Hideaki, Tohyama, Taiji, Ikegami, Toshihiko, Imura, Satoru, Shimamura, Tsuyoshi, Nakayama, Yoshimi, Urahashi, Taizen, Yamagishi, Kazumasa, Ohnishi, Hiroshi, Nagashima, Shigeo, Takahashi, Masaharu, Shirabe, Ken, Kokudo, Norihiro, Okamoto, Hiroaki, Ohkohchi, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740318/
https://www.ncbi.nlm.nih.gov/pubmed/26870785
http://dx.doi.org/10.1016/j.ebiom.2015.09.030
_version_ 1782413819953283072
author Inagaki, Yuki
Oshiro, Yukio
Tanaka, Tomohiro
Yoshizumi, Tomoharu
Okajima, Hideaki
Ishiyama, Kohei
Nakanishi, Chikashi
Hidaka, Masaaki
Wada, Hiroshi
Hibi, Taizo
Takagi, Kosei
Honda, Masaki
Kuramitsu, Kaori
Tanaka, Hideaki
Tohyama, Taiji
Ikegami, Toshihiko
Imura, Satoru
Shimamura, Tsuyoshi
Nakayama, Yoshimi
Urahashi, Taizen
Yamagishi, Kazumasa
Ohnishi, Hiroshi
Nagashima, Shigeo
Takahashi, Masaharu
Shirabe, Ken
Kokudo, Norihiro
Okamoto, Hiroaki
Ohkohchi, Nobuhiro
author_facet Inagaki, Yuki
Oshiro, Yukio
Tanaka, Tomohiro
Yoshizumi, Tomoharu
Okajima, Hideaki
Ishiyama, Kohei
Nakanishi, Chikashi
Hidaka, Masaaki
Wada, Hiroshi
Hibi, Taizo
Takagi, Kosei
Honda, Masaki
Kuramitsu, Kaori
Tanaka, Hideaki
Tohyama, Taiji
Ikegami, Toshihiko
Imura, Satoru
Shimamura, Tsuyoshi
Nakayama, Yoshimi
Urahashi, Taizen
Yamagishi, Kazumasa
Ohnishi, Hiroshi
Nagashima, Shigeo
Takahashi, Masaharu
Shirabe, Ken
Kokudo, Norihiro
Okamoto, Hiroaki
Ohkohchi, Nobuhiro
author_sort Inagaki, Yuki
collection PubMed
description BACKGROUND: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. METHODS: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. FINDINGS: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9% (54/1893), 0.05% (1/1893) and 0% (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12%) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. INTERPRETATION: The prevalence of HEV antibodies in liver transplant recipients was 2.9%, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation.
format Online
Article
Text
id pubmed-4740318
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-47403182016-02-11 A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan Inagaki, Yuki Oshiro, Yukio Tanaka, Tomohiro Yoshizumi, Tomoharu Okajima, Hideaki Ishiyama, Kohei Nakanishi, Chikashi Hidaka, Masaaki Wada, Hiroshi Hibi, Taizo Takagi, Kosei Honda, Masaki Kuramitsu, Kaori Tanaka, Hideaki Tohyama, Taiji Ikegami, Toshihiko Imura, Satoru Shimamura, Tsuyoshi Nakayama, Yoshimi Urahashi, Taizen Yamagishi, Kazumasa Ohnishi, Hiroshi Nagashima, Shigeo Takahashi, Masaharu Shirabe, Ken Kokudo, Norihiro Okamoto, Hiroaki Ohkohchi, Nobuhiro EBioMedicine Research Article BACKGROUND: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. METHODS: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. FINDINGS: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9% (54/1893), 0.05% (1/1893) and 0% (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12%) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. INTERPRETATION: The prevalence of HEV antibodies in liver transplant recipients was 2.9%, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation. Elsevier 2015-09-24 /pmc/articles/PMC4740318/ /pubmed/26870785 http://dx.doi.org/10.1016/j.ebiom.2015.09.030 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Inagaki, Yuki
Oshiro, Yukio
Tanaka, Tomohiro
Yoshizumi, Tomoharu
Okajima, Hideaki
Ishiyama, Kohei
Nakanishi, Chikashi
Hidaka, Masaaki
Wada, Hiroshi
Hibi, Taizo
Takagi, Kosei
Honda, Masaki
Kuramitsu, Kaori
Tanaka, Hideaki
Tohyama, Taiji
Ikegami, Toshihiko
Imura, Satoru
Shimamura, Tsuyoshi
Nakayama, Yoshimi
Urahashi, Taizen
Yamagishi, Kazumasa
Ohnishi, Hiroshi
Nagashima, Shigeo
Takahashi, Masaharu
Shirabe, Ken
Kokudo, Norihiro
Okamoto, Hiroaki
Ohkohchi, Nobuhiro
A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan
title A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan
title_full A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan
title_fullStr A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan
title_full_unstemmed A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan
title_short A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan
title_sort nationwide survey of hepatitis e virus infection and chronic hepatitis e in liver transplant recipients in japan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740318/
https://www.ncbi.nlm.nih.gov/pubmed/26870785
http://dx.doi.org/10.1016/j.ebiom.2015.09.030
work_keys_str_mv AT inagakiyuki anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT oshiroyukio anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT tanakatomohiro anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT yoshizumitomoharu anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT okajimahideaki anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ishiyamakohei anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT nakanishichikashi anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT hidakamasaaki anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT wadahiroshi anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT hibitaizo anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT takagikosei anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT hondamasaki anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT kuramitsukaori anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT tanakahideaki anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT tohyamataiji anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ikegamitoshihiko anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT imurasatoru anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT shimamuratsuyoshi anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT nakayamayoshimi anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT urahashitaizen anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT yamagishikazumasa anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ohnishihiroshi anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT nagashimashigeo anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT takahashimasaharu anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT shirabeken anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT kokudonorihiro anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT okamotohiroaki anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ohkohchinobuhiro anationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT inagakiyuki nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT oshiroyukio nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT tanakatomohiro nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT yoshizumitomoharu nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT okajimahideaki nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ishiyamakohei nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT nakanishichikashi nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT hidakamasaaki nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT wadahiroshi nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT hibitaizo nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT takagikosei nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT hondamasaki nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT kuramitsukaori nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT tanakahideaki nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT tohyamataiji nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ikegamitoshihiko nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT imurasatoru nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT shimamuratsuyoshi nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT nakayamayoshimi nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT urahashitaizen nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT yamagishikazumasa nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ohnishihiroshi nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT nagashimashigeo nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT takahashimasaharu nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT shirabeken nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT kokudonorihiro nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT okamotohiroaki nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan
AT ohkohchinobuhiro nationwidesurveyofhepatitisevirusinfectionandchronichepatitiseinlivertransplantrecipientsinjapan