C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation. Here we show that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours. Compared with wild-type...

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Detalles Bibliográficos
Autores principales: Bulla, Roberta, Tripodo, Claudio, Rami, Damiano, Ling, Guang Sheng, Agostinis, Chiara, Guarnotta, Carla, Zorzet, Sonia, Durigutto, Paolo, Botto, Marina, Tedesco, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740357/
https://www.ncbi.nlm.nih.gov/pubmed/26831747
http://dx.doi.org/10.1038/ncomms10346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740357/
https://www.ncbi.nlm.nih.gov/pubmed/26831747
http://dx.doi.org/10.1038/ncomms10346

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