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Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex

Here, we aimed to evaluate whether cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and primary somatosensory cortex (S1) can modulate cortical inhibitory circuits. Sixteen healthy subjects participated in this study. Cathodal tDCS was positioned over the le...

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Autores principales: Sasaki, Ryoki, Miyaguchi, Shota, Kotan, Shinichi, Kojima, Sho, Kirimoto, Hikari, Onishi, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740366/
https://www.ncbi.nlm.nih.gov/pubmed/26869909
http://dx.doi.org/10.3389/fnhum.2016.00030
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author Sasaki, Ryoki
Miyaguchi, Shota
Kotan, Shinichi
Kojima, Sho
Kirimoto, Hikari
Onishi, Hideaki
author_facet Sasaki, Ryoki
Miyaguchi, Shota
Kotan, Shinichi
Kojima, Sho
Kirimoto, Hikari
Onishi, Hideaki
author_sort Sasaki, Ryoki
collection PubMed
description Here, we aimed to evaluate whether cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and primary somatosensory cortex (S1) can modulate cortical inhibitory circuits. Sixteen healthy subjects participated in this study. Cathodal tDCS was positioned over the left M1 (M1 cathodal) or left S1 (S1 cathodal) with an intensity of 1 mA for 10 min. Sham tDCS was applied for 10 min over the left M1 (sham). Motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) were recorded from the right abductor pollicis brevis (APB) muscle before the intervention (pre) and 10 and 30 min after the intervention (post 1 and post 2, respectively). Cortical inhibitory circuits were evaluated using short-interval intracortical inhibition (SICI) and short-latency afferent inhibition (SAI). M1 cathodal decreased single-pulse MEP amplitudes at post 1 and decreased SAI at post 1 and post 2; however, SICI did not exhibit any change. S1 cathodal and sham did not show any changes in MEP amplitudes at any of the three time points. These results demonstrated that cathodal tDCS over the M1 not only decreases the M1 excitability but also affects the cortical inhibitory circuits related to SAI.
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spelling pubmed-47403662016-02-11 Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex Sasaki, Ryoki Miyaguchi, Shota Kotan, Shinichi Kojima, Sho Kirimoto, Hikari Onishi, Hideaki Front Hum Neurosci Neuroscience Here, we aimed to evaluate whether cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and primary somatosensory cortex (S1) can modulate cortical inhibitory circuits. Sixteen healthy subjects participated in this study. Cathodal tDCS was positioned over the left M1 (M1 cathodal) or left S1 (S1 cathodal) with an intensity of 1 mA for 10 min. Sham tDCS was applied for 10 min over the left M1 (sham). Motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) were recorded from the right abductor pollicis brevis (APB) muscle before the intervention (pre) and 10 and 30 min after the intervention (post 1 and post 2, respectively). Cortical inhibitory circuits were evaluated using short-interval intracortical inhibition (SICI) and short-latency afferent inhibition (SAI). M1 cathodal decreased single-pulse MEP amplitudes at post 1 and decreased SAI at post 1 and post 2; however, SICI did not exhibit any change. S1 cathodal and sham did not show any changes in MEP amplitudes at any of the three time points. These results demonstrated that cathodal tDCS over the M1 not only decreases the M1 excitability but also affects the cortical inhibitory circuits related to SAI. Frontiers Media S.A. 2016-02-04 /pmc/articles/PMC4740366/ /pubmed/26869909 http://dx.doi.org/10.3389/fnhum.2016.00030 Text en Copyright © 2016 Sasaki, Miyaguchi, Kotan, Kojima, Kirimoto and Onishi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sasaki, Ryoki
Miyaguchi, Shota
Kotan, Shinichi
Kojima, Sho
Kirimoto, Hikari
Onishi, Hideaki
Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex
title Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex
title_full Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex
title_fullStr Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex
title_full_unstemmed Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex
title_short Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex
title_sort modulation of cortical inhibitory circuits after cathodal transcranial direct current stimulation over the primary motor cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740366/
https://www.ncbi.nlm.nih.gov/pubmed/26869909
http://dx.doi.org/10.3389/fnhum.2016.00030
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