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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(−8)), of which eigh...

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Autores principales:	Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tõnu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Åsa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Mägi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M., Scott, William R., Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A. E., Walker, Ryan W., Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J. L., Bellis, Claire, Bonnefond, Amélie, Borodulin, Katja, Buchman, Aron S., Cederholm, Tommy, Choh, Audrey C., Choi, Hyung Jin, Curran, Joanne E., de Groot, Lisette C. P. G. M., De Jager, Philip L., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Evans, Daniel S., Forsen, Tom, Friedrich, Nele, Fumeron, Frédéric, Garcia, Melissa E., Gärtner, Simone, Han, Bok-Ghee, Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W., Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Leach, Irene Mateo, Lee, Christine G., Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stéphane, Loh, Marie, Lyytikäinen, Leo-Pekka, Medina-Gomez, Carolina, Michaëlsson, Karl, Nalls, Mike A., Nielson, Carrie M., Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polašek, Ozren, Ripatti, Samuli, Sarzynski, Mark A., Shin, Chan Soo, Narančić, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M. A., Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M., Verweij, Niek, Wright, Alan F., Yu, Lei, Zmuda, Joseph M., Eklund, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U., Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Männistö, Satu, Palmer, Cameron D., Ried, Janina S., Scott, Robert A., Stancáková, Alena, Wagner, Peter J., Demirkan, Ayse, Döring, Angela, Gudnason, Vilmundur, Kiel, Douglas P., Kühnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R., Oostra, Ben A., Shuldiner, Alan R., Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M., Vollenweider, Peter, White, Charles C., Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S., Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jørgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A., Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O., Wareham, Nicholas J., Bennett, David A., Bertram, Lars, Blangero, John, Blüher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H., Cummings, Steven R., Czerwinski, Stefan A., Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G., Ferrucci, Luigi, Franco, Oscar H., Froguel, Philippe, Gansevoort, Ron T., Hansen, Torben, Harris, Tamara B., Hastie, Nicholas, Heliövaara, Markku, Hofman, Albert, Jordan, Joanne M., Jula, Antti, Kähönen, Mika, Kajantie, Eero, Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Lehtimäki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Perola, Markus, Pérusse, Louis, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sørensen, Thorkild I. A., Stumvoll, Michael, Tönjes, Anke, Towne, Bradford, Tranah, Gregory J., Tremblay, Angelo, Uitterlinden, André G., van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S., Vitart, Veronique, Vohl, Marie-Claude, Völzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F., Yengo, Loïc, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S., Franke, Lude, Han, Jiali, Hunter, David J., Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C., Kooner, Jaspal S., McCarthy, Mark I., Murabito, Joanne M., Morris, Andrew P., Bishop, Julia A. N., North, Kari E., Ohlsson, Claes, Ong, Ken K., Prokopenko, Inga, Richards, J. Brent, Schadt, Eric E., Spector, Tim D., Widén, Elisabeth, Willer, Cristen J., Yang, Jian, Ingelsson, Erik, Mohlke, Karen L., Hirschhorn, Joel N., Pospisilik, John Andrew, Zillikens, M. Carola, Lindgren, Cecilia, Kilpeläinen, Tuomas Oskari, Loos, Ruth J. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398/ https://www.ncbi.nlm.nih.gov/pubmed/26833246 http://dx.doi.org/10.1038/ncomms10495

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author	Lu, Yingchang Day, Felix R. Gustafsson, Stefan Buchkovich, Martin L. Na, Jianbo Bataille, Veronique Cousminer, Diana L. Dastani, Zari Drong, Alexander W. Esko, Tõnu Evans, David M. Falchi, Mario Feitosa, Mary F. Ferreira, Teresa Hedman, Åsa K. Haring, Robin Hysi, Pirro G. Iles, Mark M. Justice, Anne E. Kanoni, Stavroula Lagou, Vasiliki Li, Rui Li, Xin Locke, Adam Lu, Chen Mägi, Reedik Perry, John R. B. Pers, Tune H. Qi, Qibin Sanna, Marianna Schmidt, Ellen M. Scott, William R. Shungin, Dmitry Teumer, Alexander Vinkhuyzen, Anna A. E. Walker, Ryan W. Westra, Harm-Jan Zhang, Mingfeng Zhang, Weihua Zhao, Jing Hua Zhu, Zhihong Afzal, Uzma Ahluwalia, Tarunveer Singh Bakker, Stephan J. L. Bellis, Claire Bonnefond, Amélie Borodulin, Katja Buchman, Aron S. Cederholm, Tommy Choh, Audrey C. Choi, Hyung Jin Curran, Joanne E. de Groot, Lisette C. P. G. M. De Jager, Philip L. Dhonukshe-Rutten, Rosalie A. M. Enneman, Anke W. Eury, Elodie Evans, Daniel S. Forsen, Tom Friedrich, Nele Fumeron, Frédéric Garcia, Melissa E. Gärtner, Simone Han, Bok-Ghee Havulinna, Aki S. Hayward, Caroline Hernandez, Dena Hillege, Hans Ittermann, Till Kent, Jack W. Kolcic, Ivana Laatikainen, Tiina Lahti, Jari Leach, Irene Mateo Lee, Christine G. Lee, Jong-Young Liu, Tian Liu, Youfang Lobbens, Stéphane Loh, Marie Lyytikäinen, Leo-Pekka Medina-Gomez, Carolina Michaëlsson, Karl Nalls, Mike A. Nielson, Carrie M. Oozageer, Laticia Pascoe, Laura Paternoster, Lavinia Polašek, Ozren Ripatti, Samuli Sarzynski, Mark A. Shin, Chan Soo Narančić, Nina Smolej Spira, Dominik Srikanth, Priya Steinhagen-Thiessen, Elisabeth Sung, Yun Ju Swart, Karin M. A. Taittonen, Leena Tanaka, Toshiko Tikkanen, Emmi van der Velde, Nathalie van Schoor, Natasja M. Verweij, Niek Wright, Alan F. Yu, Lei Zmuda, Joseph M. Eklund, Niina Forrester, Terrence Grarup, Niels Jackson, Anne U. Kristiansson, Kati Kuulasmaa, Teemu Kuusisto, Johanna Lichtner, Peter Luan, Jian'an Mahajan, Anubha Männistö, Satu Palmer, Cameron D. Ried, Janina S. Scott, Robert A. Stancáková, Alena Wagner, Peter J. Demirkan, Ayse Döring, Angela Gudnason, Vilmundur Kiel, Douglas P. Kühnel, Brigitte Mangino, Massimo Mcknight, Barbara Menni, Cristina O'Connell, Jeffrey R. Oostra, Ben A. Shuldiner, Alan R. Song, Kijoung Vandenput, Liesbeth van Duijn, Cornelia M. Vollenweider, Peter White, Charles C. Boehnke, Michael Boettcher, Yvonne Cooper, Richard S. Forouhi, Nita G. Gieger, Christian Grallert, Harald Hingorani, Aroon Jørgensen, Torben Jousilahti, Pekka Kivimaki, Mika Kumari, Meena Laakso, Markku Langenberg, Claudia Linneberg, Allan Luke, Amy Mckenzie, Colin A. Palotie, Aarno Pedersen, Oluf Peters, Annette Strauch, Konstantin Tayo, Bamidele O. Wareham, Nicholas J. Bennett, David A. Bertram, Lars Blangero, John Blüher, Matthias Bouchard, Claude Campbell, Harry Cho, Nam H. Cummings, Steven R. Czerwinski, Stefan A. Demuth, Ilja Eckardt, Rahel Eriksson, Johan G. Ferrucci, Luigi Franco, Oscar H. Froguel, Philippe Gansevoort, Ron T. Hansen, Torben Harris, Tamara B. Hastie, Nicholas Heliövaara, Markku Hofman, Albert Jordan, Joanne M. Jula, Antti Kähönen, Mika Kajantie, Eero Knekt, Paul B. Koskinen, Seppo Kovacs, Peter Lehtimäki, Terho Lind, Lars Liu, Yongmei Orwoll, Eric S. Osmond, Clive Perola, Markus Pérusse, Louis Raitakari, Olli T. Rankinen, Tuomo Rao, D. C. Rice, Treva K. Rivadeneira, Fernando Rudan, Igor Salomaa, Veikko Sørensen, Thorkild I. A. Stumvoll, Michael Tönjes, Anke Towne, Bradford Tranah, Gregory J. Tremblay, Angelo Uitterlinden, André G. van der Harst, Pim Vartiainen, Erkki Viikari, Jorma S. Vitart, Veronique Vohl, Marie-Claude Völzke, Henry Walker, Mark Wallaschofski, Henri Wild, Sarah Wilson, James F. Yengo, Loïc Bishop, D. Timothy Borecki, Ingrid B. Chambers, John C. Cupples, L. Adrienne Dehghan, Abbas Deloukas, Panos Fatemifar, Ghazaleh Fox, Caroline Furey, Terrence S. Franke, Lude Han, Jiali Hunter, David J. Karjalainen, Juha Karpe, Fredrik Kaplan, Robert C. Kooner, Jaspal S. McCarthy, Mark I. Murabito, Joanne M. Morris, Andrew P. Bishop, Julia A. N. North, Kari E. Ohlsson, Claes Ong, Ken K. Prokopenko, Inga Richards, J. Brent Schadt, Eric E. Spector, Tim D. Widén, Elisabeth Willer, Cristen J. Yang, Jian Ingelsson, Erik Mohlke, Karen L. Hirschhorn, Joel N. Pospisilik, John Andrew Zillikens, M. Carola Lindgren, Cecilia Kilpeläinen, Tuomas Oskari Loos, Ruth J. F.
author_facet	Lu, Yingchang Day, Felix R. Gustafsson, Stefan Buchkovich, Martin L. Na, Jianbo Bataille, Veronique Cousminer, Diana L. Dastani, Zari Drong, Alexander W. Esko, Tõnu Evans, David M. Falchi, Mario Feitosa, Mary F. Ferreira, Teresa Hedman, Åsa K. Haring, Robin Hysi, Pirro G. Iles, Mark M. Justice, Anne E. Kanoni, Stavroula Lagou, Vasiliki Li, Rui Li, Xin Locke, Adam Lu, Chen Mägi, Reedik Perry, John R. B. Pers, Tune H. Qi, Qibin Sanna, Marianna Schmidt, Ellen M. Scott, William R. Shungin, Dmitry Teumer, Alexander Vinkhuyzen, Anna A. E. Walker, Ryan W. Westra, Harm-Jan Zhang, Mingfeng Zhang, Weihua Zhao, Jing Hua Zhu, Zhihong Afzal, Uzma Ahluwalia, Tarunveer Singh Bakker, Stephan J. L. Bellis, Claire Bonnefond, Amélie Borodulin, Katja Buchman, Aron S. Cederholm, Tommy Choh, Audrey C. Choi, Hyung Jin Curran, Joanne E. de Groot, Lisette C. P. G. M. De Jager, Philip L. Dhonukshe-Rutten, Rosalie A. M. Enneman, Anke W. Eury, Elodie Evans, Daniel S. Forsen, Tom Friedrich, Nele Fumeron, Frédéric Garcia, Melissa E. Gärtner, Simone Han, Bok-Ghee Havulinna, Aki S. Hayward, Caroline Hernandez, Dena Hillege, Hans Ittermann, Till Kent, Jack W. Kolcic, Ivana Laatikainen, Tiina Lahti, Jari Leach, Irene Mateo Lee, Christine G. Lee, Jong-Young Liu, Tian Liu, Youfang Lobbens, Stéphane Loh, Marie Lyytikäinen, Leo-Pekka Medina-Gomez, Carolina Michaëlsson, Karl Nalls, Mike A. Nielson, Carrie M. Oozageer, Laticia Pascoe, Laura Paternoster, Lavinia Polašek, Ozren Ripatti, Samuli Sarzynski, Mark A. Shin, Chan Soo Narančić, Nina Smolej Spira, Dominik Srikanth, Priya Steinhagen-Thiessen, Elisabeth Sung, Yun Ju Swart, Karin M. A. Taittonen, Leena Tanaka, Toshiko Tikkanen, Emmi van der Velde, Nathalie van Schoor, Natasja M. Verweij, Niek Wright, Alan F. Yu, Lei Zmuda, Joseph M. Eklund, Niina Forrester, Terrence Grarup, Niels Jackson, Anne U. Kristiansson, Kati Kuulasmaa, Teemu Kuusisto, Johanna Lichtner, Peter Luan, Jian'an Mahajan, Anubha Männistö, Satu Palmer, Cameron D. Ried, Janina S. Scott, Robert A. Stancáková, Alena Wagner, Peter J. Demirkan, Ayse Döring, Angela Gudnason, Vilmundur Kiel, Douglas P. Kühnel, Brigitte Mangino, Massimo Mcknight, Barbara Menni, Cristina O'Connell, Jeffrey R. Oostra, Ben A. Shuldiner, Alan R. Song, Kijoung Vandenput, Liesbeth van Duijn, Cornelia M. Vollenweider, Peter White, Charles C. Boehnke, Michael Boettcher, Yvonne Cooper, Richard S. Forouhi, Nita G. Gieger, Christian Grallert, Harald Hingorani, Aroon Jørgensen, Torben Jousilahti, Pekka Kivimaki, Mika Kumari, Meena Laakso, Markku Langenberg, Claudia Linneberg, Allan Luke, Amy Mckenzie, Colin A. Palotie, Aarno Pedersen, Oluf Peters, Annette Strauch, Konstantin Tayo, Bamidele O. Wareham, Nicholas J. Bennett, David A. Bertram, Lars Blangero, John Blüher, Matthias Bouchard, Claude Campbell, Harry Cho, Nam H. Cummings, Steven R. Czerwinski, Stefan A. Demuth, Ilja Eckardt, Rahel Eriksson, Johan G. Ferrucci, Luigi Franco, Oscar H. Froguel, Philippe Gansevoort, Ron T. Hansen, Torben Harris, Tamara B. Hastie, Nicholas Heliövaara, Markku Hofman, Albert Jordan, Joanne M. Jula, Antti Kähönen, Mika Kajantie, Eero Knekt, Paul B. Koskinen, Seppo Kovacs, Peter Lehtimäki, Terho Lind, Lars Liu, Yongmei Orwoll, Eric S. Osmond, Clive Perola, Markus Pérusse, Louis Raitakari, Olli T. Rankinen, Tuomo Rao, D. C. Rice, Treva K. Rivadeneira, Fernando Rudan, Igor Salomaa, Veikko Sørensen, Thorkild I. A. Stumvoll, Michael Tönjes, Anke Towne, Bradford Tranah, Gregory J. Tremblay, Angelo Uitterlinden, André G. van der Harst, Pim Vartiainen, Erkki Viikari, Jorma S. Vitart, Veronique Vohl, Marie-Claude Völzke, Henry Walker, Mark Wallaschofski, Henri Wild, Sarah Wilson, James F. Yengo, Loïc Bishop, D. Timothy Borecki, Ingrid B. Chambers, John C. Cupples, L. Adrienne Dehghan, Abbas Deloukas, Panos Fatemifar, Ghazaleh Fox, Caroline Furey, Terrence S. Franke, Lude Han, Jiali Hunter, David J. Karjalainen, Juha Karpe, Fredrik Kaplan, Robert C. Kooner, Jaspal S. McCarthy, Mark I. Murabito, Joanne M. Morris, Andrew P. Bishop, Julia A. N. North, Kari E. Ohlsson, Claes Ong, Ken K. Prokopenko, Inga Richards, J. Brent Schadt, Eric E. Spector, Tim D. Widén, Elisabeth Willer, Cristen J. Yang, Jian Ingelsson, Erik Mohlke, Karen L. Hirschhorn, Joel N. Pospisilik, John Andrew Zillikens, M. Carola Lindgren, Cecilia Kilpeläinen, Tuomas Oskari Loos, Ruth J. F.
author_sort	Lu, Yingchang
collection	PubMed
description	To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(−8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
format	Online Article Text
id	pubmed-4740398
institution	National Center for Biotechnology Information
language	English
publishDate	2016
publisher	Nature Publishing Group
record_format	MEDLINE/PubMed
spelling	pubmed-47403982016-03-04 New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk Lu, Yingchang Day, Felix R. Gustafsson, Stefan Buchkovich, Martin L. Na, Jianbo Bataille, Veronique Cousminer, Diana L. Dastani, Zari Drong, Alexander W. Esko, Tõnu Evans, David M. Falchi, Mario Feitosa, Mary F. Ferreira, Teresa Hedman, Åsa K. Haring, Robin Hysi, Pirro G. Iles, Mark M. Justice, Anne E. Kanoni, Stavroula Lagou, Vasiliki Li, Rui Li, Xin Locke, Adam Lu, Chen Mägi, Reedik Perry, John R. B. Pers, Tune H. Qi, Qibin Sanna, Marianna Schmidt, Ellen M. Scott, William R. Shungin, Dmitry Teumer, Alexander Vinkhuyzen, Anna A. E. Walker, Ryan W. Westra, Harm-Jan Zhang, Mingfeng Zhang, Weihua Zhao, Jing Hua Zhu, Zhihong Afzal, Uzma Ahluwalia, Tarunveer Singh Bakker, Stephan J. L. Bellis, Claire Bonnefond, Amélie Borodulin, Katja Buchman, Aron S. Cederholm, Tommy Choh, Audrey C. Choi, Hyung Jin Curran, Joanne E. de Groot, Lisette C. P. G. M. De Jager, Philip L. Dhonukshe-Rutten, Rosalie A. M. Enneman, Anke W. Eury, Elodie Evans, Daniel S. Forsen, Tom Friedrich, Nele Fumeron, Frédéric Garcia, Melissa E. Gärtner, Simone Han, Bok-Ghee Havulinna, Aki S. Hayward, Caroline Hernandez, Dena Hillege, Hans Ittermann, Till Kent, Jack W. Kolcic, Ivana Laatikainen, Tiina Lahti, Jari Leach, Irene Mateo Lee, Christine G. Lee, Jong-Young Liu, Tian Liu, Youfang Lobbens, Stéphane Loh, Marie Lyytikäinen, Leo-Pekka Medina-Gomez, Carolina Michaëlsson, Karl Nalls, Mike A. Nielson, Carrie M. Oozageer, Laticia Pascoe, Laura Paternoster, Lavinia Polašek, Ozren Ripatti, Samuli Sarzynski, Mark A. Shin, Chan Soo Narančić, Nina Smolej Spira, Dominik Srikanth, Priya Steinhagen-Thiessen, Elisabeth Sung, Yun Ju Swart, Karin M. A. Taittonen, Leena Tanaka, Toshiko Tikkanen, Emmi van der Velde, Nathalie van Schoor, Natasja M. Verweij, Niek Wright, Alan F. Yu, Lei Zmuda, Joseph M. Eklund, Niina Forrester, Terrence Grarup, Niels Jackson, Anne U. Kristiansson, Kati Kuulasmaa, Teemu Kuusisto, Johanna Lichtner, Peter Luan, Jian'an Mahajan, Anubha Männistö, Satu Palmer, Cameron D. Ried, Janina S. Scott, Robert A. Stancáková, Alena Wagner, Peter J. Demirkan, Ayse Döring, Angela Gudnason, Vilmundur Kiel, Douglas P. Kühnel, Brigitte Mangino, Massimo Mcknight, Barbara Menni, Cristina O'Connell, Jeffrey R. Oostra, Ben A. Shuldiner, Alan R. Song, Kijoung Vandenput, Liesbeth van Duijn, Cornelia M. Vollenweider, Peter White, Charles C. Boehnke, Michael Boettcher, Yvonne Cooper, Richard S. Forouhi, Nita G. Gieger, Christian Grallert, Harald Hingorani, Aroon Jørgensen, Torben Jousilahti, Pekka Kivimaki, Mika Kumari, Meena Laakso, Markku Langenberg, Claudia Linneberg, Allan Luke, Amy Mckenzie, Colin A. Palotie, Aarno Pedersen, Oluf Peters, Annette Strauch, Konstantin Tayo, Bamidele O. Wareham, Nicholas J. Bennett, David A. Bertram, Lars Blangero, John Blüher, Matthias Bouchard, Claude Campbell, Harry Cho, Nam H. Cummings, Steven R. Czerwinski, Stefan A. Demuth, Ilja Eckardt, Rahel Eriksson, Johan G. Ferrucci, Luigi Franco, Oscar H. Froguel, Philippe Gansevoort, Ron T. Hansen, Torben Harris, Tamara B. Hastie, Nicholas Heliövaara, Markku Hofman, Albert Jordan, Joanne M. Jula, Antti Kähönen, Mika Kajantie, Eero Knekt, Paul B. Koskinen, Seppo Kovacs, Peter Lehtimäki, Terho Lind, Lars Liu, Yongmei Orwoll, Eric S. Osmond, Clive Perola, Markus Pérusse, Louis Raitakari, Olli T. Rankinen, Tuomo Rao, D. C. Rice, Treva K. Rivadeneira, Fernando Rudan, Igor Salomaa, Veikko Sørensen, Thorkild I. A. Stumvoll, Michael Tönjes, Anke Towne, Bradford Tranah, Gregory J. Tremblay, Angelo Uitterlinden, André G. van der Harst, Pim Vartiainen, Erkki Viikari, Jorma S. Vitart, Veronique Vohl, Marie-Claude Völzke, Henry Walker, Mark Wallaschofski, Henri Wild, Sarah Wilson, James F. Yengo, Loïc Bishop, D. Timothy Borecki, Ingrid B. Chambers, John C. Cupples, L. Adrienne Dehghan, Abbas Deloukas, Panos Fatemifar, Ghazaleh Fox, Caroline Furey, Terrence S. Franke, Lude Han, Jiali Hunter, David J. Karjalainen, Juha Karpe, Fredrik Kaplan, Robert C. Kooner, Jaspal S. McCarthy, Mark I. Murabito, Joanne M. Morris, Andrew P. Bishop, Julia A. N. North, Kari E. Ohlsson, Claes Ong, Ken K. Prokopenko, Inga Richards, J. Brent Schadt, Eric E. Spector, Tim D. Widén, Elisabeth Willer, Cristen J. Yang, Jian Ingelsson, Erik Mohlke, Karen L. Hirschhorn, Joel N. Pospisilik, John Andrew Zillikens, M. Carola Lindgren, Cecilia Kilpeläinen, Tuomas Oskari Loos, Ruth J. F. Nat Commun Article To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(−8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. Nature Publishing Group 2016-02-01 /pmc/articles/PMC4740398/ /pubmed/26833246 http://dx.doi.org/10.1038/ncomms10495 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle	Article Lu, Yingchang Day, Felix R. Gustafsson, Stefan Buchkovich, Martin L. Na, Jianbo Bataille, Veronique Cousminer, Diana L. Dastani, Zari Drong, Alexander W. Esko, Tõnu Evans, David M. Falchi, Mario Feitosa, Mary F. Ferreira, Teresa Hedman, Åsa K. Haring, Robin Hysi, Pirro G. Iles, Mark M. Justice, Anne E. Kanoni, Stavroula Lagou, Vasiliki Li, Rui Li, Xin Locke, Adam Lu, Chen Mägi, Reedik Perry, John R. B. Pers, Tune H. Qi, Qibin Sanna, Marianna Schmidt, Ellen M. Scott, William R. Shungin, Dmitry Teumer, Alexander Vinkhuyzen, Anna A. E. Walker, Ryan W. Westra, Harm-Jan Zhang, Mingfeng Zhang, Weihua Zhao, Jing Hua Zhu, Zhihong Afzal, Uzma Ahluwalia, Tarunveer Singh Bakker, Stephan J. L. Bellis, Claire Bonnefond, Amélie Borodulin, Katja Buchman, Aron S. Cederholm, Tommy Choh, Audrey C. Choi, Hyung Jin Curran, Joanne E. de Groot, Lisette C. P. G. M. De Jager, Philip L. Dhonukshe-Rutten, Rosalie A. M. Enneman, Anke W. Eury, Elodie Evans, Daniel S. Forsen, Tom Friedrich, Nele Fumeron, Frédéric Garcia, Melissa E. Gärtner, Simone Han, Bok-Ghee Havulinna, Aki S. Hayward, Caroline Hernandez, Dena Hillege, Hans Ittermann, Till Kent, Jack W. Kolcic, Ivana Laatikainen, Tiina Lahti, Jari Leach, Irene Mateo Lee, Christine G. Lee, Jong-Young Liu, Tian Liu, Youfang Lobbens, Stéphane Loh, Marie Lyytikäinen, Leo-Pekka Medina-Gomez, Carolina Michaëlsson, Karl Nalls, Mike A. Nielson, Carrie M. Oozageer, Laticia Pascoe, Laura Paternoster, Lavinia Polašek, Ozren Ripatti, Samuli Sarzynski, Mark A. Shin, Chan Soo Narančić, Nina Smolej Spira, Dominik Srikanth, Priya Steinhagen-Thiessen, Elisabeth Sung, Yun Ju Swart, Karin M. A. Taittonen, Leena Tanaka, Toshiko Tikkanen, Emmi van der Velde, Nathalie van Schoor, Natasja M. Verweij, Niek Wright, Alan F. Yu, Lei Zmuda, Joseph M. Eklund, Niina Forrester, Terrence Grarup, Niels Jackson, Anne U. Kristiansson, Kati Kuulasmaa, Teemu Kuusisto, Johanna Lichtner, Peter Luan, Jian'an Mahajan, Anubha Männistö, Satu Palmer, Cameron D. Ried, Janina S. Scott, Robert A. Stancáková, Alena Wagner, Peter J. Demirkan, Ayse Döring, Angela Gudnason, Vilmundur Kiel, Douglas P. Kühnel, Brigitte Mangino, Massimo Mcknight, Barbara Menni, Cristina O'Connell, Jeffrey R. Oostra, Ben A. Shuldiner, Alan R. Song, Kijoung Vandenput, Liesbeth van Duijn, Cornelia M. Vollenweider, Peter White, Charles C. Boehnke, Michael Boettcher, Yvonne Cooper, Richard S. Forouhi, Nita G. Gieger, Christian Grallert, Harald Hingorani, Aroon Jørgensen, Torben Jousilahti, Pekka Kivimaki, Mika Kumari, Meena Laakso, Markku Langenberg, Claudia Linneberg, Allan Luke, Amy Mckenzie, Colin A. Palotie, Aarno Pedersen, Oluf Peters, Annette Strauch, Konstantin Tayo, Bamidele O. Wareham, Nicholas J. Bennett, David A. Bertram, Lars Blangero, John Blüher, Matthias Bouchard, Claude Campbell, Harry Cho, Nam H. Cummings, Steven R. Czerwinski, Stefan A. Demuth, Ilja Eckardt, Rahel Eriksson, Johan G. Ferrucci, Luigi Franco, Oscar H. Froguel, Philippe Gansevoort, Ron T. Hansen, Torben Harris, Tamara B. Hastie, Nicholas Heliövaara, Markku Hofman, Albert Jordan, Joanne M. Jula, Antti Kähönen, Mika Kajantie, Eero Knekt, Paul B. Koskinen, Seppo Kovacs, Peter Lehtimäki, Terho Lind, Lars Liu, Yongmei Orwoll, Eric S. Osmond, Clive Perola, Markus Pérusse, Louis Raitakari, Olli T. Rankinen, Tuomo Rao, D. C. Rice, Treva K. Rivadeneira, Fernando Rudan, Igor Salomaa, Veikko Sørensen, Thorkild I. A. Stumvoll, Michael Tönjes, Anke Towne, Bradford Tranah, Gregory J. Tremblay, Angelo Uitterlinden, André G. van der Harst, Pim Vartiainen, Erkki Viikari, Jorma S. Vitart, Veronique Vohl, Marie-Claude Völzke, Henry Walker, Mark Wallaschofski, Henri Wild, Sarah Wilson, James F. Yengo, Loïc Bishop, D. Timothy Borecki, Ingrid B. Chambers, John C. Cupples, L. Adrienne Dehghan, Abbas Deloukas, Panos Fatemifar, Ghazaleh Fox, Caroline Furey, Terrence S. Franke, Lude Han, Jiali Hunter, David J. Karjalainen, Juha Karpe, Fredrik Kaplan, Robert C. Kooner, Jaspal S. McCarthy, Mark I. Murabito, Joanne M. Morris, Andrew P. Bishop, Julia A. N. North, Kari E. Ohlsson, Claes Ong, Ken K. Prokopenko, Inga Richards, J. Brent Schadt, Eric E. Spector, Tim D. Widén, Elisabeth Willer, Cristen J. Yang, Jian Ingelsson, Erik Mohlke, Karen L. Hirschhorn, Joel N. Pospisilik, John Andrew Zillikens, M. Carola Lindgren, Cecilia Kilpeläinen, Tuomas Oskari Loos, Ruth J. F. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_full	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_fullStr	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_full_unstemmed	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_short	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_sort	new loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
topic	Article
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398/ https://www.ncbi.nlm.nih.gov/pubmed/26833246 http://dx.doi.org/10.1038/ncomms10495
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newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT raitakariollit newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT rankinentuomo newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT raodc newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ricetrevak newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT rivadeneirafernando newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT rudanigor newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT salomaaveikko newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT sørensenthorkildia newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT stumvollmichael newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT tonjesanke newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT townebradford newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT tranahgregoryj newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT tremblayangelo newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT uitterlindenandreg newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT vanderharstpim newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT vartiainenerkki newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT viikarijormas newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT vitartveronique newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT vohlmarieclaude newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT volzkehenry newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT walkermark newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT wallaschofskihenri newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT wildsarah newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT wilsonjamesf newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT yengoloic newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT bishopdtimothy newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT boreckiingridb newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT chambersjohnc newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT cupplesladrienne newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT dehghanabbas newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT deloukaspanos newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT fatemifarghazaleh newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT foxcaroline newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT fureyterrences newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT frankelude newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT hanjiali newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT hunterdavidj newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT karjalainenjuha newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT karpefredrik newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT kaplanrobertc newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT koonerjaspals newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT mccarthymarki newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT murabitojoannem newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT morrisandrewp newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT bishopjuliaan newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT northkarie newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ohlssonclaes newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ongkenk newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT prokopenkoinga newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT richardsjbrent newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT schadterice newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT spectortimd newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT widenelisabeth newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT willercristenj newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT yangjian newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ingelssonerik newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT mohlkekarenl newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT hirschhornjoeln newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT pospisilikjohnandrew newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT zillikensmcarola newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT lindgrencecilia newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT kilpelainentuomasoskari newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT loosruthjf newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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