MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity v...

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Detalles Bibliográficos
Autores principales: Kwon, Duk-Hwa, Eom, Gwang Hyeon, Ko, Jeong Hyeon, Shin, Sera, Joung, Hosouk, Choe, Nakwon, Nam, Yoon Seok, Min, Hyun-Ki, Kook, Taewon, Yoon, Somy, Kang, Wanseok, Kim, Yong Sook, Kim, Hyung Seok, Choi, Hyuck, Koh, Jeong-Tae, Kim, Nacksung, Ahn, Youngkeun, Cho, Hyun-Jai, Lee, In-Kyu, Park, Dong Ho, Suk, Kyoungho, Seo, Sang Beom, Wissing, Erin R., Mendrysa, Susan M., Nam, Kwang-Il, Kook, Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740400/
https://www.ncbi.nlm.nih.gov/pubmed/26832969
http://dx.doi.org/10.1038/ncomms10492

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