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Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

INTRODUCTION: Left ventricular dysfunction is a frequent and potentially severe side effect of many tyrosine kinase inhibitors (TKI). The mode of toxicity is not identified, but may include impairment of mitochondrial or sarcomeric function, autophagy or angiogenesis, either as an on-target or off-t...

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Detalles Bibliográficos
Autores principales:	Jacob, Fabian, Yonis, Amina Y., Cuello, Friederike, Luther, Pradeep, Schulze, Thomas, Eder, Alexandra, Streichert, Thomas, Mannhardt, Ingra, Hirt, Marc N., Schaaf, Sebastian, Stenzig, Justus, Force, Thomas, Eschenhagen, Thomas, Hansen, Arne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740402/ https://www.ncbi.nlm.nih.gov/pubmed/26840448 http://dx.doi.org/10.1371/journal.pone.0145937

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