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Phylogenomic and biogeographic reconstruction of the Trichinella complex

Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systemat...

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Autores principales: Korhonen, Pasi K., Pozio, Edoardo, La Rosa, Giuseppe, Chang, Bill C. H., Koehler, Anson V., Hoberg, Eric P., Boag, Peter R., Tan, Patrick, Jex, Aaron R., Hofmann, Andreas, Sternberg, Paul W., Young, Neil D., Gasser, Robin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740406/
https://www.ncbi.nlm.nih.gov/pubmed/26830005
http://dx.doi.org/10.1038/ncomms10513
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author Korhonen, Pasi K.
Pozio, Edoardo
La Rosa, Giuseppe
Chang, Bill C. H.
Koehler, Anson V.
Hoberg, Eric P.
Boag, Peter R.
Tan, Patrick
Jex, Aaron R.
Hofmann, Andreas
Sternberg, Paul W.
Young, Neil D.
Gasser, Robin B.
author_facet Korhonen, Pasi K.
Pozio, Edoardo
La Rosa, Giuseppe
Chang, Bill C. H.
Koehler, Anson V.
Hoberg, Eric P.
Boag, Peter R.
Tan, Patrick
Jex, Aaron R.
Hofmann, Andreas
Sternberg, Paul W.
Young, Neil D.
Gasser, Robin B.
author_sort Korhonen, Pasi K.
collection PubMed
description Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and show that encapsulated and non-encapsulated Trichinella taxa diverged from their most recent common ancestor ∼21 million years ago (mya), with taxon diversifications commencing ∼10−7 mya.
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spelling pubmed-47404062016-03-04 Phylogenomic and biogeographic reconstruction of the Trichinella complex Korhonen, Pasi K. Pozio, Edoardo La Rosa, Giuseppe Chang, Bill C. H. Koehler, Anson V. Hoberg, Eric P. Boag, Peter R. Tan, Patrick Jex, Aaron R. Hofmann, Andreas Sternberg, Paul W. Young, Neil D. Gasser, Robin B. Nat Commun Article Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and show that encapsulated and non-encapsulated Trichinella taxa diverged from their most recent common ancestor ∼21 million years ago (mya), with taxon diversifications commencing ∼10−7 mya. Nature Publishing Group 2016-02-01 /pmc/articles/PMC4740406/ /pubmed/26830005 http://dx.doi.org/10.1038/ncomms10513 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Korhonen, Pasi K.
Pozio, Edoardo
La Rosa, Giuseppe
Chang, Bill C. H.
Koehler, Anson V.
Hoberg, Eric P.
Boag, Peter R.
Tan, Patrick
Jex, Aaron R.
Hofmann, Andreas
Sternberg, Paul W.
Young, Neil D.
Gasser, Robin B.
Phylogenomic and biogeographic reconstruction of the Trichinella complex
title Phylogenomic and biogeographic reconstruction of the Trichinella complex
title_full Phylogenomic and biogeographic reconstruction of the Trichinella complex
title_fullStr Phylogenomic and biogeographic reconstruction of the Trichinella complex
title_full_unstemmed Phylogenomic and biogeographic reconstruction of the Trichinella complex
title_short Phylogenomic and biogeographic reconstruction of the Trichinella complex
title_sort phylogenomic and biogeographic reconstruction of the trichinella complex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740406/
https://www.ncbi.nlm.nih.gov/pubmed/26830005
http://dx.doi.org/10.1038/ncomms10513
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