Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy

OBJECTIVES: Marfan syndrome is an autosomal dominant inherited disorder of connective tissue. The vascular complications of Marfan syndrome have the biggest impact on life expectancy. The aorta of Marfan patients reveals degradation of elastin layers caused by increased proteolytic activity of matri...

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Detalles Bibliográficos
Autores principales: Seppelt, Philipp Christian, Schwill, Simon, Weymann, Alexander, Arif, Rawa, Weber, Antje, Zaradzki, Marcin, Richter, Karsten, Ensminger, Stephan, Robinson, Peter Nicholas, Wagner, Andreas H., Karck, Matthias, Kallenbach, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740453/
https://www.ncbi.nlm.nih.gov/pubmed/26840980
http://dx.doi.org/10.1371/journal.pone.0148012

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