Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage

Osteopontin (OPN), a secreted protein involved in inflammatory processes and cancer, induces cell adhesion, migration, and activation of inflammatory pathways in various cell types. Cells bind OPN via integrins at a canonical RGD region in the full length form as well as to a contiguous cryptic site...

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Detalles Bibliográficos
Autores principales: Jürets, Alexander, Le Bras, Marie, Staffler, Günther, Stein, Gesine, Leitner, Lukas, Neuhofer, Angelika, Tardelli, Matteo, Turkof, Edvin, Zeyda, Maximilian, Stulnig, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740464/
https://www.ncbi.nlm.nih.gov/pubmed/26840958
http://dx.doi.org/10.1371/journal.pone.0148333

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