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Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740739/ https://www.ncbi.nlm.nih.gov/pubmed/26836814 http://dx.doi.org/10.1038/ncomms10165 |
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| author | Benoit, Joshua B. Adelman, Zach N. Reinhardt, Klaus Dolan, Amanda Poelchau, Monica Jennings, Emily C. Szuter, Elise M. Hagan, Richard W. Gujar, Hemant Shukla, Jayendra Nath Zhu, Fang Mohan, M. Nelson, David R. Rosendale, Andrew J. Derst, Christian Resnik, Valentina Wernig, Sebastian Menegazzi, Pamela Wegener, Christian Peschel, Nicolai Hendershot, Jacob M. Blenau, Wolfgang Predel, Reinhard Johnston, Paul R. Ioannidis, Panagiotis Waterhouse, Robert M. Nauen, Ralf Schorn, Corinna Ott, Mark-Christoph Maiwald, Frank Johnston, J. Spencer Gondhalekar, Ameya D. Scharf, Michael E. Peterson, Brittany F. Raje, Kapil R. Hottel, Benjamin A. Armisén, David Crumière, Antonin Jean Johan Refki, Peter Nagui Santos, Maria Emilia Sghaier, Essia Viala, Sèverine Khila, Abderrahman Ahn, Seung-Joon Childers, Christopher Lee, Chien-Yueh Lin, Han Hughes, Daniel S. T. Duncan, Elizabeth J. Murali, Shwetha C. Qu, Jiaxin Dugan, Shannon Lee, Sandra L. Chao, Hsu Dinh, Huyen Han, Yi Doddapaneni, Harshavardhan Worley, Kim C. Muzny, Donna M. Wheeler, David Panfilio, Kristen A. Vargas Jentzsch, Iris M. Vargo, Edward L. Booth, Warren Friedrich, Markus Weirauch, Matthew T. Anderson, Michelle A. E. Jones, Jeffery W. Mittapalli, Omprakash Zhao, Chaoyang Zhou, Jing-Jiang Evans, Jay D. Attardo, Geoffrey M. Robertson, Hugh M. Zdobnov, Evgeny M. Ribeiro, Jose M. C. Gibbs, Richard A. Werren, John H. Palli, Subba R. Schal, Coby Richards, Stephen |
| author_facet | Benoit, Joshua B. Adelman, Zach N. Reinhardt, Klaus Dolan, Amanda Poelchau, Monica Jennings, Emily C. Szuter, Elise M. Hagan, Richard W. Gujar, Hemant Shukla, Jayendra Nath Zhu, Fang Mohan, M. Nelson, David R. Rosendale, Andrew J. Derst, Christian Resnik, Valentina Wernig, Sebastian Menegazzi, Pamela Wegener, Christian Peschel, Nicolai Hendershot, Jacob M. Blenau, Wolfgang Predel, Reinhard Johnston, Paul R. Ioannidis, Panagiotis Waterhouse, Robert M. Nauen, Ralf Schorn, Corinna Ott, Mark-Christoph Maiwald, Frank Johnston, J. Spencer Gondhalekar, Ameya D. Scharf, Michael E. Peterson, Brittany F. Raje, Kapil R. Hottel, Benjamin A. Armisén, David Crumière, Antonin Jean Johan Refki, Peter Nagui Santos, Maria Emilia Sghaier, Essia Viala, Sèverine Khila, Abderrahman Ahn, Seung-Joon Childers, Christopher Lee, Chien-Yueh Lin, Han Hughes, Daniel S. T. Duncan, Elizabeth J. Murali, Shwetha C. Qu, Jiaxin Dugan, Shannon Lee, Sandra L. Chao, Hsu Dinh, Huyen Han, Yi Doddapaneni, Harshavardhan Worley, Kim C. Muzny, Donna M. Wheeler, David Panfilio, Kristen A. Vargas Jentzsch, Iris M. Vargo, Edward L. Booth, Warren Friedrich, Markus Weirauch, Matthew T. Anderson, Michelle A. E. Jones, Jeffery W. Mittapalli, Omprakash Zhao, Chaoyang Zhou, Jing-Jiang Evans, Jay D. Attardo, Geoffrey M. Robertson, Hugh M. Zdobnov, Evgeny M. Ribeiro, Jose M. C. Gibbs, Richard A. Werren, John H. Palli, Subba R. Schal, Coby Richards, Stephen |
| author_sort | Benoit, Joshua B. |
| collection | PubMed |
| description | The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite. |
| format | Online Article Text |
| id | pubmed-4740739 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47407392016-03-04 Unique features of a global human ectoparasite identified through sequencing of the bed bug genome Benoit, Joshua B. Adelman, Zach N. Reinhardt, Klaus Dolan, Amanda Poelchau, Monica Jennings, Emily C. Szuter, Elise M. Hagan, Richard W. Gujar, Hemant Shukla, Jayendra Nath Zhu, Fang Mohan, M. Nelson, David R. Rosendale, Andrew J. Derst, Christian Resnik, Valentina Wernig, Sebastian Menegazzi, Pamela Wegener, Christian Peschel, Nicolai Hendershot, Jacob M. Blenau, Wolfgang Predel, Reinhard Johnston, Paul R. Ioannidis, Panagiotis Waterhouse, Robert M. Nauen, Ralf Schorn, Corinna Ott, Mark-Christoph Maiwald, Frank Johnston, J. Spencer Gondhalekar, Ameya D. Scharf, Michael E. Peterson, Brittany F. Raje, Kapil R. Hottel, Benjamin A. Armisén, David Crumière, Antonin Jean Johan Refki, Peter Nagui Santos, Maria Emilia Sghaier, Essia Viala, Sèverine Khila, Abderrahman Ahn, Seung-Joon Childers, Christopher Lee, Chien-Yueh Lin, Han Hughes, Daniel S. T. Duncan, Elizabeth J. Murali, Shwetha C. Qu, Jiaxin Dugan, Shannon Lee, Sandra L. Chao, Hsu Dinh, Huyen Han, Yi Doddapaneni, Harshavardhan Worley, Kim C. Muzny, Donna M. Wheeler, David Panfilio, Kristen A. Vargas Jentzsch, Iris M. Vargo, Edward L. Booth, Warren Friedrich, Markus Weirauch, Matthew T. Anderson, Michelle A. E. Jones, Jeffery W. Mittapalli, Omprakash Zhao, Chaoyang Zhou, Jing-Jiang Evans, Jay D. Attardo, Geoffrey M. Robertson, Hugh M. Zdobnov, Evgeny M. Ribeiro, Jose M. C. Gibbs, Richard A. Werren, John H. Palli, Subba R. Schal, Coby Richards, Stephen Nat Commun Article The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite. Nature Publishing Group 2016-02-02 /pmc/articles/PMC4740739/ /pubmed/26836814 http://dx.doi.org/10.1038/ncomms10165 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Benoit, Joshua B. Adelman, Zach N. Reinhardt, Klaus Dolan, Amanda Poelchau, Monica Jennings, Emily C. Szuter, Elise M. Hagan, Richard W. Gujar, Hemant Shukla, Jayendra Nath Zhu, Fang Mohan, M. Nelson, David R. Rosendale, Andrew J. Derst, Christian Resnik, Valentina Wernig, Sebastian Menegazzi, Pamela Wegener, Christian Peschel, Nicolai Hendershot, Jacob M. Blenau, Wolfgang Predel, Reinhard Johnston, Paul R. Ioannidis, Panagiotis Waterhouse, Robert M. Nauen, Ralf Schorn, Corinna Ott, Mark-Christoph Maiwald, Frank Johnston, J. Spencer Gondhalekar, Ameya D. Scharf, Michael E. Peterson, Brittany F. Raje, Kapil R. Hottel, Benjamin A. Armisén, David Crumière, Antonin Jean Johan Refki, Peter Nagui Santos, Maria Emilia Sghaier, Essia Viala, Sèverine Khila, Abderrahman Ahn, Seung-Joon Childers, Christopher Lee, Chien-Yueh Lin, Han Hughes, Daniel S. T. Duncan, Elizabeth J. Murali, Shwetha C. Qu, Jiaxin Dugan, Shannon Lee, Sandra L. Chao, Hsu Dinh, Huyen Han, Yi Doddapaneni, Harshavardhan Worley, Kim C. Muzny, Donna M. Wheeler, David Panfilio, Kristen A. Vargas Jentzsch, Iris M. Vargo, Edward L. Booth, Warren Friedrich, Markus Weirauch, Matthew T. Anderson, Michelle A. E. Jones, Jeffery W. Mittapalli, Omprakash Zhao, Chaoyang Zhou, Jing-Jiang Evans, Jay D. Attardo, Geoffrey M. Robertson, Hugh M. Zdobnov, Evgeny M. Ribeiro, Jose M. C. Gibbs, Richard A. Werren, John H. Palli, Subba R. Schal, Coby Richards, Stephen Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_full | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_fullStr | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_full_unstemmed | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_short | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| title_sort | unique features of a global human ectoparasite identified through sequencing of the bed bug genome |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740739/ https://www.ncbi.nlm.nih.gov/pubmed/26836814 http://dx.doi.org/10.1038/ncomms10165 |
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