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Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units
How complex natural sounds are represented by the main converging center of the auditory midbrain, the central inferior colliculus, is an open question. We applied neural discrimination to determine the variation of detailed encoding of individual vocalizations across the best frequency gradient of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740783/ https://www.ncbi.nlm.nih.gov/pubmed/26869890 http://dx.doi.org/10.3389/fncir.2015.00091 |
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author | Lyzwa, Dominika Herrmann, J. Michael Wörgötter, Florentin |
author_facet | Lyzwa, Dominika Herrmann, J. Michael Wörgötter, Florentin |
author_sort | Lyzwa, Dominika |
collection | PubMed |
description | How complex natural sounds are represented by the main converging center of the auditory midbrain, the central inferior colliculus, is an open question. We applied neural discrimination to determine the variation of detailed encoding of individual vocalizations across the best frequency gradient of the central inferior colliculus. The analysis was based on collective responses from several neurons. These multi-unit spike trains were recorded from guinea pigs exposed to a spectrotemporally rich set of eleven species-specific vocalizations. Spike trains of disparate units from the same recording were combined in order to investigate whether groups of multi-unit clusters represent the whole set of vocalizations more reliably than only one unit, and whether temporal response correlations between them facilitate an unambiguous neural representation of the vocalizations. We found a spatial distribution of the capability to accurately encode groups of vocalizations across the best frequency gradient. Different vocalizations are optimally discriminated at different locations of the best frequency gradient. Furthermore, groups of a few multi-unit clusters yield improved discrimination over only one multi-unit cluster between all tested vocalizations. However, temporal response correlations between units do not yield better discrimination. Our study is based on a large set of units of simultaneously recorded responses from several guinea pigs and electrode insertion positions. Our findings suggest a broadly distributed code for behaviorally relevant vocalizations in the mammalian inferior colliculus. Responses from a few non-interacting units are sufficient to faithfully represent the whole set of studied vocalizations with diverse spectrotemporal properties. |
format | Online Article Text |
id | pubmed-4740783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47407832016-02-11 Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units Lyzwa, Dominika Herrmann, J. Michael Wörgötter, Florentin Front Neural Circuits Neuroscience How complex natural sounds are represented by the main converging center of the auditory midbrain, the central inferior colliculus, is an open question. We applied neural discrimination to determine the variation of detailed encoding of individual vocalizations across the best frequency gradient of the central inferior colliculus. The analysis was based on collective responses from several neurons. These multi-unit spike trains were recorded from guinea pigs exposed to a spectrotemporally rich set of eleven species-specific vocalizations. Spike trains of disparate units from the same recording were combined in order to investigate whether groups of multi-unit clusters represent the whole set of vocalizations more reliably than only one unit, and whether temporal response correlations between them facilitate an unambiguous neural representation of the vocalizations. We found a spatial distribution of the capability to accurately encode groups of vocalizations across the best frequency gradient. Different vocalizations are optimally discriminated at different locations of the best frequency gradient. Furthermore, groups of a few multi-unit clusters yield improved discrimination over only one multi-unit cluster between all tested vocalizations. However, temporal response correlations between units do not yield better discrimination. Our study is based on a large set of units of simultaneously recorded responses from several guinea pigs and electrode insertion positions. Our findings suggest a broadly distributed code for behaviorally relevant vocalizations in the mammalian inferior colliculus. Responses from a few non-interacting units are sufficient to faithfully represent the whole set of studied vocalizations with diverse spectrotemporal properties. Frontiers Media S.A. 2016-02-01 /pmc/articles/PMC4740783/ /pubmed/26869890 http://dx.doi.org/10.3389/fncir.2015.00091 Text en Copyright © 2016 Lyzwa, Herrmann and Wörgötter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lyzwa, Dominika Herrmann, J. Michael Wörgötter, Florentin Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units |
title | Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units |
title_full | Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units |
title_fullStr | Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units |
title_full_unstemmed | Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units |
title_short | Natural Vocalizations in the Mammalian Inferior Colliculus are Broadly Encoded by a Small Number of Independent Multi-Units |
title_sort | natural vocalizations in the mammalian inferior colliculus are broadly encoded by a small number of independent multi-units |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740783/ https://www.ncbi.nlm.nih.gov/pubmed/26869890 http://dx.doi.org/10.3389/fncir.2015.00091 |
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