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Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology

Metformin, a drug prescribed to treat type-2 diabetes, exhibits anti-cancer effects in a portion of patients, but the direct molecular and genetic interactions leading to this pleiotropic effect have not yet been fully explored. To repurpose metformin as a precision anti-cancer therapy, we have deve...

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Detalles Bibliográficos
Autores principales:	Hart, Thomas, Dider, Shihab, Han, Weiwei, Xu, Hua, Zhao, Zhongming, Xie, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740793/ https://www.ncbi.nlm.nih.gov/pubmed/26841718 http://dx.doi.org/10.1038/srep20441

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